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Electron Microscopic Changes in Colon in Experimental Swine Dysentery

Elektron-mikroskopiske forandringer i kolon ved eksperimentell svinedysenteri

Acta Veterinaria Scandinavica volume 20, pages 224–237 (1979)Cite this article

Abstract

Colonic lesions in experimental swine dysentery were studied electron microscopically. Changes indicative of stasis were commonly observed in the microcirculatory vessels of lamina propria. Early lesions in epithelial cells included sparse, short and irregular microvilli, swollen and degenerated mitochondria, and swelling and vesiculation of endoplasmatic reticulum. Numerous large spirochaetes were observed in these locations: a) in the crypts, b) free (i.e. not membrane bound) in cytoplasm of damaged epithelial cells, and c) in cavities, around vessels of lamina propria. It is suggested that stasis, and resultant disturbances in microcirculation in early developmental stages of swine dysentery, may play a pathogenetic role in the development of the necrotic colonic lesions. Finally, it is discussed whether a mechanism related to Sanarelli-Shwartzman reaction is implicated in the development of colonic lesions in swine dysentery.

Sammendrag

De pato-anatomiske forandringer i kolon ved eksperimentell svinedysenteri ble studert i elektronmikroskopet. I de sniå blodkar i stratum proprium ble det påvist forandringer som tydet på stase. De ultrastrukturelle forandringene i epitelcellene besto i relativt tidlige stadier av redusert antall, forkortelse og deformitet av microvilli; mitokondriene var oppsvulmet og degenererte, og det oppsto større og mindre blæredannelser i det endoplasmatiske reticulum. Spirochæter, i stort antall og med distinkte strukturer, ble påvist a) i kryptene i kolon, b) fritt (ikke membran-bundet) i degenererte epitelceller, og c) i lommedannelser omkring blodkar i stratum proprium. Det antydes at stase inntrer på et relativt tidlig stadium i utviklingen av svinedysenteri, og at de nekrotiske forandringene som etter hvert utvikles kan ha direkte sammenheng med stase. Det diskuteres også hvorvidt forandringene i kolon ved svinedysenteri kan tenkes å være utviklet over en patogenetisk mekanisme av typen Sanarelli-Shwartzman’s reaksjon.

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Authors and Affiliations

  1. National Veterinary Institute, Dep., Oslo 1, P. O. Box 8156, Oslo, Norway

    Jon Teige Jr. & Knut Nordstoga

  2. Department of Pathology, Veterinary College of Norway, Oslo, Norway

    Jon Teige Jr. & Knut Nordstoga

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  1. Jon Teige Jr.
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  2. Knut Nordstoga
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Teige, J., Nordstoga, K. Electron Microscopic Changes in Colon in Experimental Swine Dysentery. Acta Vet Scand 20, 224–237 (1979). https://doi.org/10.1186/BF03546614

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Acta Veterinaria Scandinavica

ISSN: 1751-0147