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Selenium and Vitamin E Deficiency in Pigs

II. Influence on Plasma Selenium, Vitamin E, Asat and Alat and on Tissue Selenium

Selen- og vitamin E mangel hos svin. II. Indflydelse på Se og Vit. E plasma- og Se vævsværdier samt plasma ASAT og ALAT

Acta Veterinaria Scandinavica volume 20, pages 289–305 (1979)Cite this article

Abstract

The effect of dietary selenium (Se) and vitamin E (Vit. E) in pigs on Se and Vit. E in plasma and on Se in tissue from liver, heart, m. long, dorsi and m. psoas major was studied; and furthermore was the influence on the enzymes ASAT and ALAT studied.

Two levels of Se were used, 0.03 and 0.06 mg Se per kg feed. Within each Se level 2 levels of Vit. E were used, 15 and 45 i. u. per kg feed. This resulted in 4 groups: 1. low Se and low Vit. E; 2. low Se and high Vit. E; 3. high Se and low Vit. E; 4. high Se and high Vit. E.

Ten% of all pigs fed low Se, and 4% of the pigs fed low Se and high Vit. E diet died with severe symptoms of Se deficiency. None of the pigs fed the high Se diet died with such symptoms. Plasma Se determinations have been shown to indicate the Se status in pigs almost as accurately as liver Se determination. ASAT and ALAT enzyme determinations were not of any diagnostic value.

There was a good agreement between dietary Vit. E level and the corresponding levels in plasma. Oxidized herring oil seems to enhance the Vit. E need.

Sammendrag

Virkningen af perorait tilført seien (Se) og vitamin E (Vit. E) på plasmaværdierne for Se, Vit. E og transaminaser (ASAT og ALAT) samt på vævsvserdier for Se er blevet undersøgt.

To niveauer af Se blev tilført, nemlig 0,03 og 0,06 mg pr. kg foder. Hvert af holdene på de 2 Se niveauer blev igen opdelt i to, nemlig et hold med foder indeholdende 15 I. E. Vit. E og et med 45 I.E. pr. kg foder. Herved fremkom 4 grupper: 1. Lav Se, lav Vit. E; 2. Lav Se, høj Vit. E; 3. Høj Se, lav Vit. E og 4. Høj Se, høj Vit. E.

Ti% af grisene på lav Se, lav Vit. E, og 4% af grisene på lav Se, høj Vit. E døde med udtalte symptomer på Se mangel. Ingen af de grise, som fik foder med højt Se indhold, viste sådanne symptomer. Plasma Se bestemmelserne viste sig at reflektere grisenes Se status naesten ligeså akkurat som Se bestemmelser på levervsev. ASAT og ALAT plasma enzymbestemmelser viste sig med de benyttede blodprøveudtagelsestidspunkter at vaere uden diagnostisk vserdi. Plasma Se bestemmelser udført på blodprøver udtaget i tilslutning til aflivning med elektrisk bedøvning viste betydelig højere vaerdier end prøver udtaget umiddelbart før slagtningen.

Forsøgene viste, at der er god overensstemmelse imellem foderets Vit. E indhold og de tilsvarende niveauer i plasma. Oksyderet sildeolie synes at forøge grisenes Vit. E behov.

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Authors and Affiliations

  1. Institute of Internal Medicine and the Department for Anatomical Pathology, Royal Veterinary and Agricultural University, Bülowsvej 13, Copenhagen V, DK-1870, Copenhagen, Denmark

    M. G. Simesen, H. E. Nielsen, V. Danielsen, G. Gissel-Nielsen, W. Hjarde, T. Leth & A. Basse

  2. Department for Experiments with Pigs and Horses, National Institute of Animal Science, Copenhagen, Denmark

    M. G. Simesen, H. E. Nielsen, V. Danielsen, G. Gissel-Nielsen, W. Hjarde, T. Leth & A. Basse

  3. Risø National Laboratory, Roskilde, Denmark

    M. G. Simesen, H. E. Nielsen, V. Danielsen, G. Gissel-Nielsen, W. Hjarde, T. Leth & A. Basse

  4. Division of Chemical Determination of Nutrients, National Food Institute, Søborg, Denmark

    M. G. Simesen, H. E. Nielsen, V. Danielsen, G. Gissel-Nielsen, W. Hjarde, T. Leth & A. Basse

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  1. M. G. Simesen
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  2. H. E. Nielsen
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  3. V. Danielsen
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  4. G. Gissel-Nielsen
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  5. W. Hjarde
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  7. A. Basse
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This investigation was supported by a grant from the Danish Agricultural and Veterinary Research Council.

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Simesen, M.G., Nielsen, H.E., Danielsen, V. et al. Selenium and Vitamin E Deficiency in Pigs. Acta Vet Scand 20, 289–305 (1979). https://doi.org/10.1186/BF03546620

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Acta Veterinaria Scandinavica

ISSN: 1751-0147