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Plasma Cortisol in the Horse, Diurnal Rhythm and Effects of Exogenous Acth
Cortisol i hästplasma, dygnsrytm och inverkan av ACTH-injektion
Acta Veterinaria Scandinavica volume 20, pages 16–24 (1979)
Abstract
Peripheral blood plasma Cortisol concentration and its diurnal variation was measured in 4 horses. Mean concentration of Cortisol during 24 hrs. was 42 ng/ml (s ± 20 ng/ml). Peak values occurred at 6 a.m. and the lowest values were observed at about 6 p.m. (mean 65 ng/ml and 20 ng/ml, respectively).
Long-acting ACTH at a dose of 150 i.u. was given by intramuscular injection to the 4 horses. Peak Cortisol concentrations markedly exceeding the prestimulation level were obtained between 2 and 4 hrs. after injection. During the immediate 24 hrs. after these peaks, the mean Cortisol level was markedly lower and the cyclic variation out of phase with the basal diurnal pattern. After a gradual adjustment during the second postinjection day, no differences could be seen between the 2 patterns on day 3 after injection.
Sammanfattning
Cortisolkoncentrationen i perifer blodplasma och dess dygnsvariation mättes på fyra hästar. Medelkoncentrationen av Cortisol under 24 timmar var 42 ng/ml (s ± 20 ng/ml). Högsta värdena uppmättes klockan 06 och lägsta omkring klockan 18 (medelvärden 65 ng/ml respektive 20 ng/ml).
Vid i.m. injektion av 150 IE långtidsverkande ACTH erhölls maximala cortisolkoncentrationer efter 2 till 4 timmar hos de fyra hästarna. Under de följande 24 timmarna var cortisolnivåerna markant lägre och dygnsrytmen förskjuten i förhållande till det basala mönstret. Under andra dagen efter injektionen skedde en gradvis justering och tre dagar efter injektionen kunde inga skillnader mellan de båda mönstren påvisas.
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Larsson, M., Edqvist, LE., Ekman, L. et al. Plasma Cortisol in the Horse, Diurnal Rhythm and Effects of Exogenous Acth. Acta Vet Scand 20, 16–24 (1979). https://doi.org/10.1186/BF03546625
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DOI: https://doi.org/10.1186/BF03546625