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Elicitation of the Generalized Shwartzman Reaction in Rabbits with Parenteral Iron Preparations and Bacterial Endotoxin

Utlösning av den generella Shwartzmanreaktionen med parenterala järnpreparat och bakteriellt endotoxin hos kaniner

Acta Veterinaria Scandinavica volume 16, pages 226–235 (1975)Cite this article

Abstract

Some parenteral iron preparations were examined regarding their ability to act as preparing agents in the elicitation of the generalized Shwartzman reaction in the rabbit. As expression of the generalized Shwartzman reaction bilateral cortical necrosis of the kidneys was demonstrated when Imferon, Iroject, Macofer, and A 2152 were used as preparing agents. No renal lesion was observed when Jectofer was used.

Sammanfattning

Några olika järnpreparat undersöktes beträffande deras förmåga att vara “preparing agents” vid utlösandet av den generella Shwartzmanreaktionen hos kanin. Som uttryck för den generella Shwartzmanreaktionen påvisades bilateral kortikal nekros i njurarna när Imferon, Iroject, Macofer och A 2152 användes som “preparing agents”. Ingen njurskada iakttogs, när Jectofer användes.

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Authors and Affiliations

  1. Research and Development Laboratories, Astra Läkemedel, and the Toxicology Laboratories, Astra Pharmaceuticals, S-151 85, Södertälje, Sweden

    Hans Eriksson & Göran Magnusson

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  1. Hans Eriksson
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  2. Göran Magnusson
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Eriksson, H., Magnusson, G. Elicitation of the Generalized Shwartzman Reaction in Rabbits with Parenteral Iron Preparations and Bacterial Endotoxin. Acta Vet Scand 16, 226–235 (1975). https://doi.org/10.1186/BF03546677

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Acta Veterinaria Scandinavica

ISSN: 1751-0147