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Factors Affecting the Hypocalcaemic Response to Protamine

Olika faktorers inverkan på det hypokalcemiska svaret av protamin

Acta Veterinaria Scandinavica volume 16, pages 51–62 (1975)Cite this article

Abstract

The hypocalcaemic response to protamine, as a measure of bone resorption rate, was studied in cattle and sheep. Three groups of calves were studied (1–3 days, 2–3 weeks and 4 months old). The oldest calves showed the greatest response, indicating a more rapid skeletal turnover in these animals, probably related to a higher growing rate. A group of cows was tested at 2 occasions, near parturition and 2–3 weeks after parturition. The decrease in plasma calcium was small near parturition, while a profound drop was obtained 2–3 weeks post partum, which supports earlier findings that bone resorption is more or less blocked in parturient cows. Young pregnant ewes showed the same degree of hypocalcaemia as adult pregnant ewes but the recovery was more rapid in the young animals. Young rams were given protamine before and after diethylstilboestrol treatment. No differences in calcium response were obtained. Varying plasma phosphate responses were obtained. A pronounced hyperphosphataemia was found in the adult pregnant ewes. Diethylstilboestrol caused hypermagnesaemia in the rams.

Sammanfattning

Det hypokalcemiska svaret av protamin, som ett mått på benresorptionen, studerades hos nötkreatur och får. Tre grupper av kalvar undersöktes (1–3 dagar, 2–3 veckor samt 4 månader gamla). De äldsta kalvarna visade den kraftigaste kalciumsänkningen, vilket tolkades som en snabbare „turnover” i dessa djurs skelett, troligen relaterad till en högre tillväxttakt. En grupp av kor testades vid två tillfällen, nära förlossningen samt 2–3 veckor efter förlossningen. Kalciumsänkningen var liten vid första tillfället, medan en uttalad hypokalcemi erhölls vid andra infusionen. Resultaten stöder tidigare uppgifter om att benresorptionen är mer eller mindre blockerad hos kor vid tiden för förlossning. Unga dräktiga tackor uppvisade samma grad av hypokalcemi som gamla dräktiga tackor. Hos de unga djuren skedde emellertid normaliseringen av plasmakalcium snabbare. Unga baggar erhöll injektioner med protamin före och efter behandling med dietylstilboestrol. Kalciumsvaret var detsamma vid båda tillfällena. Varierande svar i halten av oorganiskt fosfor erhölls. De gamla dräktiga tackorna uppvisade en påtaglig hyperfosfatemi. Behandling med dietylstilboestrol medförde hypermagnesemi hos ungbaggarna.

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  1. Department of Medicine II, Royal Veterinary College, S-104 05, Stockholm 50, Sweden

    Jan Persson & Jan Luthman

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  1. Jan Persson
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  2. Jan Luthman
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Persson, J., Luthman, J. Factors Affecting the Hypocalcaemic Response to Protamine. Acta Vet Scand 16, 51–62 (1975). https://doi.org/10.1186/BF03546695

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Acta Veterinaria Scandinavica

ISSN: 1751-0147