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Studies on Pentagastrin-Induced Hypocalcaemia in Lactating Cows

Studier över pentagastrininducerad hypokalcemi hos lakterande kor

Acta Veterinaria Scandinavica volume 16, pages 126–133 (1975)Cite this article

Abstract

During recent years it has been evident that a number of gastrointestinal hormones are potent calcitonin secretagogues, and it has been suggested that a gastrointestinal-thyroid C cell system exists as a part of post prandial calcium homeostasis. In the present study the hypocalcaemic effect of pentagastrin, a synthetic peptide with gastrin effects, was studied in lactating cows. Intravenous infusion of pentagastrin caused marked hypocalcaemia and hypophosphataemia in the cows. Thyroidectomy completely abolished the hypocalcaemic and hypophosphataemic effects of the peptide. The results thus suggested that the effects of the peptide were due to release of endogenous calcitonin.

Sammanfattning

Under senare år har det visats att fiera gastrointestinala hormoner kan frisätta calcitonin och det har föreslagits att gastrointestinala hormoner spelar en viss roll i kalciumhomeostasen, framför allt när det gäller att förhindra hyperkalcemi efter en måltid. Den hypokalcemiska effekten av pentagastrin, en syntetisk peptide med gastrineffekt, studerades hos lakterande kor. Intravenös infusion av pentagastrin gav påtagliga sänkningar av plasmakoncentrationerna av kalcium och oorganisk fosfor. Dessa effekter kunde dock helt elimineras av thyroidektomi. Resultaten talade således för att de observerade effekterna orsakades av en ökad frisättning av endogent calcitonin.

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Authors and Affiliations

  1. Department of Medicine II, Royal Veterinary College, S-104 50, Stockholm 50, Sweden

    J. Luthman, J. Persson & S. O. Jacobsson

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  1. J. Luthman
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  2. J. Persson
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  3. S. O. Jacobsson
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Luthman, J., Persson, J. & Jacobsson, S.O. Studies on Pentagastrin-Induced Hypocalcaemia in Lactating Cows. Acta Vet Scand 16, 126–133 (1975). https://doi.org/10.1186/BF03546701

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Acta Veterinaria Scandinavica

ISSN: 1751-0147