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Inheritance of an Abnormal Haemoglobin Haplotype in Horses and its Possible Influence on Blood Values
Nedaruing av en unormal hemoglobin (Hb) haplotype hos best og dens mulige innvirkning på blodverdier
Acta Veterinaria Scandinavica volume 24, pages 384–391 (1983)
Abstract
In a breeding experiment a stallion of the native Norwegian Trotter breed with an abnormal Hb haplotype (N) and with the Hb type BI/N, sired 6 offspring. The abnormal haplotype controls one α-chain only, having lysine at position 60 and phenylalanine at position 24. Three of the offspring received the N haplotype from the sire and the BII haplotype from the dam, whereas the other 3 offspring received BI from the sire. The BII/N horses have two Hb components after alkaline electrophoresis or isoelectric focusing with the ratio between the fast and the slow band (anodal, cathodal) being approximately 30:70. Blood value determinations did not give any definite conclusions as regards differences between horses with the abnormal Hb type and normal horses of similar age within the same breed.
Sammendrag
En Norsk Traver hingst med en unormal Hb haplotype (N) og med Hb type BI/N fikk i et avlsfors0k seks avkom. Den unormale haplotype kontrollerer en a-kjede. Denne har lysin i posisjon nr. 60 og fenylalanin i posisjon nr. 24. Tre avkom fikk N haplotypen fra hingsten og BII fra hoppen, mens de tre andre avkom fikk BI fra hingsten. Hestene med Hb typen BII/N viser to Hb komponenter etter elektroforese i alkalisk miljø eller isoelektrisk fokusering. Forholdet mellom den hurtigste og den saktere komponent (anode—katode) er omtrent 30:70. Bestemmelser av blodverdier viste ingen sikre for-skjeller mellom de hester som har den unormale Hb type og normale hester av tilsvarende alder og rase.
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Braend, M., Clegg, J.B. & Storset, A. Inheritance of an Abnormal Haemoglobin Haplotype in Horses and its Possible Influence on Blood Values. Acta Vet Scand 24, 384–391 (1983). https://doi.org/10.1186/BF03546712
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DOI: https://doi.org/10.1186/BF03546712