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Drug Withdrawal from Farmed Fish
Tilbakeholdelse ved behandling au oppdrettsfisk. Utskilling au oxy-tetracyklin, sulfadiazin og trimethoprim fra muskelueu hos regnbue-ørret (Salmo gairdneri)
Depletion of Oxytetracycyline, Sulfadiazine, and Trimethophrim from Muscular Tissue of Rainbow Trout (Salmo Gairdneri)
Acta Veterinaria Scandinavica volume 24, pages 418–430 (1983)
Abstract
A statistical approach to the setting of withdrawal times is presented. It is suggested that the time intercept between detection limit of the applied method of analysis, and the 90 % upper prediction limit of a linear regression on the logarithm of the tissue drug concentration provides a realistic estimate of the necessary withdrawal period at the temperatures considered. Recognizing that water temperature is an important determinant of pharcnaco-kinetics in fish, temperature-dependent withholding periods are recommended, i.e. 60 days at temperatures above 10°G and, for oxytetracycline, 100 days at temperatures between 7 and 10°G. The observed persistence of sulfadiazine and trimethoprim at lower water temperatures indicates that this drug mixture should be applied to slaughter fish only during summer.
Sammendrag
Det presen teres en statistisk metode for bestemmelse av nødven-dige tilbakeholdelsesfrister. Skjseringspunktet mellom analysemetodens følsomhet og den 0vre grense for et 90 % konfidensintervall for enkelt-observasjoner for den lineœre regresjonsfunksjon som beskriver sam-menhengen mellom logaritmen av vevskonsentrasjon og tid, ansees å gi et realistisk anslag på nødvendig tilbakeholdelser under de gitte temperaturforhold. På grunn av vanntemperaturens betydning for utskilling av farmaka hos fisk, anbefales temperaturavhengige tilbakeholdelsesfrister. Etter behandling med oxytetracyklin innebaerer dette en tilbakeholdelsesfrist på 60 døgn ved vanntemperaturer over 10° G og 100 døgn ved tempearturer mellom 7 og 10 °C. Det anbefales videre at kombinasjonen sulfadiazin-trimethoprim anvendes til slaktefisk bare i sommerhalvåret.
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This study was financially supported by the Agricultural Research Council of Norway.
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Salte, R., Liestøl, K. Drug Withdrawal from Farmed Fish. Acta Vet Scand 24, 418–430 (1983). https://doi.org/10.1186/BF03546715
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DOI: https://doi.org/10.1186/BF03546715