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Teratogenic Effects of the Organophosphorus Compound Fenchlorphos in Rabbits
Teratogen effekt av fosforinsektisidet fenklorfos på kanin
Acta Veterinaria Scandinavica volume 24, pages 295–304 (1983)
Abstract
Fenchlorphos was administered orally in doses of 0, 12.5, 25 and 50 mg per kg to pregnant rabbits from day 6 to 18 of gestation. No effect on implantation efficacy, number of live fetuses, or fetal weight was observed. The incidence of major malformations such as cardiovascular and brain anomalies was, however, increased in the medicated groups. Major skeletal malformations were more frequent in the medicated groups; minor skeletal variation were about equal in all groups. Dose-relationship was observed for cardiovascular malformations and cerebellar hypoplasia.
Sammendrag
Ektoparasittmiddelet fenklorfos (0.0-dimethyl-0-(2,4,5ntriklorofe-nyl)fosforthioat) ble administrert i doser på 0, 12.5, 25 og 50 mg per kg til drektige Belted Dutch kaniner fra 6. til 18. drektighetsdag. Be-handlingen hadde ingen effekt på implantasjonstall, antall levende foster, fostervekt, eller kjønnsfordeling hos fostrene.
Det var forøket antall misdannede fostre i de doserte gruppene sainmenlignet med kontrollgruppene. Misdannelsene omfattet hjerte-kar, hjerne og skjelett.
Histologisk undersøkelse av cerebellum viste hypoplasi av cere-bellarcortex i høyeste og nest høyeste, men ikke i laveste dosegruppe.
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Nafstad, I., Berge, G., Sannes, E. et al. Teratogenic Effects of the Organophosphorus Compound Fenchlorphos in Rabbits. Acta Vet Scand 24, 295–304 (1983). https://doi.org/10.1186/BF03546733
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DOI: https://doi.org/10.1186/BF03546733