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Ovarian and Testicular Function in the Blue Fox (Alopex Lagopus) after Oral Administration of Fenchlorphos During the Breeding Season
Ovarie- og testikkelfunksjon hos blåreu (Alopex lagopus) etter oral administrering av fenklorfos i aulssesongen
Acta Veterinaria Scandinavica volume 24, pages 200–210 (1983)
Abstract
The possible effect of fenchlorphos, 0-0-dimethy1-0-(2.4.5-trichlorophenyl) phosphorothioate, upon the reproductive endocrinology in blue foxes (Alopex lagopus) was investigated. Five females were administered fenchlorphos orally at a dose of 100 mg/kg daily from 10 days before oestrus and up to the 21st day of gestation. This dose represents the therapeutic dose for the treatment of sarcoptic mange. Blood samples were collected for the analyses of progesterone, oestradiol-17β and luteinizing hormone (LH) in plasma. The vixens were ovario-hysterectomized on day 23, except 1 animal in the control group which was operated on day 17. Additionally, sperm quality and mating performance in 3 male blue foxes, which were administered 100 mg/kg fenchlorphos daily during the first 3 weeks of the mating season, were examined.
Pregnancy was recorded in 2 medicated and 4 control animals. No pathological changes were observed in the uterus and the ovaries. The plasma concentrations of the hormones were similar to those obtained from the control group. No evidence of any disturbances concerning spermatogenesis in the males was observed. However, their libido appeared to be reduced. None of the males achieved a mating during and after the period of medication.
Sammendrag
Fenklorfos, 0-0-dimetyl-0-(2.4.5-triklorofenyl) fosforotioat, 100 mg/kg/dag, ble administrert oralt til fern blårevtisper fra 10 dager før østrus til 21. drektighetsdag for å undersøke den eventuelle effekten av komponenten på det endokrine reproduksjonssystemet. Doseringen som ble valgt representerer den terapeutiske dose ved behandling av Sarcoptes skabb hos blårev. Blodpr0ver ble tatt til analyser av pro-gesteron, østradiol-17β og luteiniserende hormon (LH) i plasma. Tispene ble ovariehysterektomert på dag 23 i drektigheten, unntatt ett dyr i kontrollgruppa som ble operert på dag 17. I tillegg ble sædkvaliteten og parringsvilligheten hos tre hanrever, som ble gitt fenklorfos 100 mg/kg daglig i de tre første ukene av parringssesongen, undersøkt.
Drektighet ble observert hos 2 forsøksdyr og 4 kontrolldyr. Ingen patologiske forandringer ble registrert i uterus og ovarier. Konsentra-sjonen av hormoner i plasma viste et forholdsvis likt mønster mellom forsøksgruppe og kontrollgruppe. Det forelå ingen holdepunkter for å anta en forstyrrelse av Spermatogenesen hos hanrevene. Imidlertid syntes revenes libido å være nedsatt. Ingen av hannene var i stand til å utføre parring under og etter medikamenteringsperioden.
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Berge, G.N., Mondain-Monval, M., Smith, A. et al. Ovarian and Testicular Function in the Blue Fox (Alopex Lagopus) after Oral Administration of Fenchlorphos During the Breeding Season. Acta Vet Scand 24, 200–210 (1983). https://doi.org/10.1186/BF03546747
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DOI: https://doi.org/10.1186/BF03546747