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Acid-Base and Electrolyte Changes in 1–3 Days Old Piglets Infected with Enteropathogenic Escherichia Coli and in Spontaneous Cases of Piglet Diarrhoea
Syra-bas och elektrolytförändringar hos 1–3 dagar gamla spädgrisar infekterade med enteropatogena Escherichia coli och hos sporttana fall av spädgrisdiarré
Acta Veterinaria Scandinavica volume 24, pages 84–98 (1983)
Abstract
Infection perorally with enteropathogenic E. coli (ST +LT) bacteria in 57 newborn piglets gave rise to watery diarrhoea in 50 (88%) piglets and was lethal in 17 (34 %) cases. The diarrhoea was associated with a progressing partially compensated metabolic acidosis indicated by significantly decreased pH, pCO2 and RE values. The acidosis (BE-values) was significantly correlated with increased blood LA and serum K+ values. The dehydration during the disease was confirmed by increased Hb, Hct, serum protein and urea values as well as loss of weight. The changes were most pronounced in piglets that died and a BE value of —10 mmol/1 seemed to be a critical limit at which the prognosis could be considered poor.
The changes in acid-base status and water balance was confirmed in 64 piglets with spontaneous cases of E. coli diarrhoea.
Sammanfattning
Nyfödda spädgrisar (57 st) infekterades perorait med ent er opatogena E. coli (ST + LT) bakterier. Av dessa utvecklade 50 st (88 %) en vattentunn diarré med dödlig utgånig i 17 fall (34 %). Diarrégrisarna utvecklade en delvis kompenserad metabolisk ácidos, vilket manifeste-rades genom signifikanta sänkningar av pH, BE och pGO2 värden. Acidosen (BE-värdena) var signifikant korrelerad till ökade LA värden i blod och till ökade serum K+-värden. Dehydreringen under sjuk-domen bekräftades av ökade Hb, Htk, serumprotein och urea värden i kombination meid viktsförlust. Förändrinigarna var mest uttalade hos de grisar som dog. Ett BE-värde på —10 mmol/1 föreföll vara en gräns under vilket prognosen kunde förutsägas vara dålig.
Förändringarna i syra-bas status och vätskebalans bekräftades hos 64 st spädigrisar med spontana fall av E. coli diarré.
References
Andren, B.: Arterial acid-base measurements in 1–3 days old piglets. Acta vet. scarad. 1982, 23, 581–591.
Argenzio, R. A. & S. C. Whipp: Pathophysiology of Diarrhoea. In: Veterinary Gastroenterology. Lea & Febiger, Philadelphia 1980, p. 200–232.
Bywater, R. J. & G. N. Woode: Oral fluid replacement by a glucose glycine electrolyte formulation in E. coli and rotavirus diarrhoea in pigs. Vet. Rec. 1980, 106, 75–78.
Boyd, J. W.: The relationships between blood haemoglobin concentration, packed cell volume and plasma protein concentration in dehydration. Brit. vet. J. 1981, 137, 166–172.
Colton, T.: Statistics in Medicine. Little, Brown and Company 1974.
Fisher, E. W. & A. D. McEwan: Death in neonatal calf diarrhoea. II: The role of oxygen and potassium. Brit. vet. J. 1967, 123, 4–7.
Kildeberg, P.: Clinical Acid-Base Physiology. Munksgaard, Copenhagen 1968.
Kutas, F. & J. Szabó: Effect of diarrhoea on the water and acid-base balance in piglets with enteric coliibacillosis. Acta vet. Acad. Sci. hung. 1971, 21, 117–125.
Lonnroth, I., B. Andren, S. Lange, K. Martinsson & J. Holmgren: Chlor-promazine reverses diarrhoea in piglets caused by enterotoxigenic Escherichia coli. Infect. Immun. 1979, 24, 900–905.
Moon, H. W.: Pathogenesis of enteric diseases caused by Escherichia coli. Ad vane. vet. Sci. comp. Med. 1974, 18, 179–211.
Moon, H. W., N. O. Nielsen & T. T. Kramer: Experimental enteric coli-bacillosis of the newborn pig: Histopathology of the small intestine and changes in plasma electrolytes. Amer. J. vet. Res. 1970, 31, 103–112.
Pierce, N. F. & N. Hirschhorn: Oral fluid — A simple weapon against dehydration in diarrhoea. How it works and how to use it. WHO Chron. 1977, 31, 87–93.
Pownall, R.: Fluid and electrolyte metabolism of neonatal pigs. I. Variation with age in blood and plasma composition. Brit. vet. J. 1970, 126, 465–469.
Rooth, G.: Syra-bas, elektrolyt- och vätskebalans. (Acid-base, electrolyte and water balance). Studenitlitteratur, Lund 1974.
Sack, B.: Pathogenesis and Pathophysiology of Diarrhoeal Diseases Caused by Vibrio eholerae and enterotoxigenic Escherichia coli. Cholera and Related Diarrhoeas. 43th Nobel Symposium, Karger, Basel 1980.
Staples, G. E.: Tolerance of piglets to injected fluids. Brit. vet. J. 1980, 136, 492–495.
Soderlind, O.: Studies on Escherichia coli in pigs. I. Biochemical investigations. Zbl. Vet.-Med. B. 1971 a, 18, 489–504.
Soderlind, O.: Studies on Escherichia coli in pigs. II. Serological investigations. Zbl. Vet.-Med. B. 1971 b, 18, 569–590.
Soderlind, O. & R. Möllby: Studies on Escherichia coli in pigs. V. Determination of enterotoxicity and frequency of 0 groups and K88 antigen in strains from 200 piglets with neonatal diarrhoea. Zbl. Vet.-Med. B. 1978, 25, 719–728,
Tumbleson, M. E. & P. R. Kalish: Serum biochemical and hematological parameters in crossbred swine from birth through eight weeks of age. Canad. J. comp. Med. 1972, 36, 202–209.
Weichelbaum, T. E.: An accurate and rapid method for the determination of proteins in small amounts of blood serum and plasma. Amer. J. clin. Path. 1946, 10, 40–49.
Whipp, S. C. & H. W. Moon: Modification of enterosorption in experimental enteric colibacillosis of swine inoculated with Escherichia coli. J. infect. Dis. 1973, 127, 255–260.
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This investigation was supported by grants from the Swedish Council for Forestry and Agricultural Research.
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Andrén, B., Persson, S. Acid-Base and Electrolyte Changes in 1–3 Days Old Piglets Infected with Enteropathogenic Escherichia Coli and in Spontaneous Cases of Piglet Diarrhoea. Acta Vet Scand 24, 84–98 (1983). https://doi.org/10.1186/BF03546760
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DOI: https://doi.org/10.1186/BF03546760