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Oxytetragyclines in Cattle
Oxytetracyklin til kvæg — Sammenligning mellem et konventionelt og et prolong er et præparat
A Comparison Between a Conventional and a Long-Acting Preparation
Acta Veterinaria Scandinavica volume 24, pages 120–128 (1983)
Abstract
Pharmacokinetics of oxytetracycline (OTC) were studied in 4 cows after administration of either a conventional (OTC-C) or a long-acting (OTC-LA) preparation. After intravenous administration of OTG-G the elimination half-life for OTG was found to be 6 h. Intramuscular injection of OTC-C and OTC-LA resulted in almost identical plasma concentrations of OTC with peak values after 6–8 h. For both preparations the bioavailability after i.m. administration was 100 % and about 60 % of the dose was excreted in the urine during the first week. Plasma concentrations above 0.5 μg/ml were with both preparations maintained for approximately 60 h, indicating no retard effect of OTC-LA as compared to OTC-C.
Sammendrag
Oxytetracyklin (OTC) findes som injektionsvaeske til veterinser brug i en konventionel (OTG-C) og en „long-acting” (OTÓLA) præparation. I den foreliggende undersøgelse er de to praeparater sam-menlignet i 12 forsøg på 4 køer.
Efter intravenøs injektion of OTG-G fandtes eliminationshalve-ringstiden for OTG til 6 timer og 55–60 % af den injicerede dosis blev udskilt med urinen i løbet af den første uge.
Intramuskulaer injektion af ens doser af OTG-G og OTC-LA resul-terede i naesten identiske plasmakoncentrationskurver med højeste koncentration efter 6–8 timer. Sammenlignet med de plasmavaBrdier, der opnåedes ved intravenøs injektion, fandtes biotilgængeligheden for begge præparater efter intramuskulaer administration at vaere ca. 100 %, og ca. 60 % af dosis kunne genfindes i urinen.
Plasmakoncentrationer over 0.5 μg/ml kunne for så vel OTG-G som OTG-LA opretholdes i ca. 60 timer efter en intramuskulaer injektion af 20 mg/kg lgv.
Da der således ikke kunne påvises en forlaenget virkningstid for OTG-LA siammenlignet med OTC-C, og da det i andre unders0gelser er vist, at OTG-LA fremkalder betydelig mere vaevsbeskadigelse på injektionsstedet end OTC-G, må det konkluderes, at hos kvæg frem-byder OTG-LA ingen fordele i forhold til OTC-C.
References
Baggot, J. D.: Principles of Drug Disposition in Domestic Animals: The Basis of Veterinary Clinical Pharmacology. W. B. Saunders & Co., Philadelphia 1977, pp. 155–158.
Bonsnes, R. N. & H. H. Taussky: On the colorimetric determination of creatinine by the Jaffe reaction. J. biol. Chem. 1945, 158, 581–591.
Bretzlaff, K. N., R. S. Ott, G. D. Koritz, T. F. Lock, R. F. Bevill, R. V. Shawley, B. K. Gustafsson & L. E. Davis: Distribution of oxy-tetracycline in the genital tract of cows. Amer. J. vet. Res. 1982, 43, 12–16.
Comwell, R. L.: Evaluation of a long-acting injectable oxytetracycline. Mod. vet. Pract. 1980, 61, 945–947.
Fourtillan, J. B. & D. Dubourg: Pharmacocinetiques sanguine et tissu-laire de l’oxytetracycline après administration de la terramy-cine longue action chez la vache. (Pharmacokinetics of long-acting terramycin in cattle). Pharmacologic et Toxicologic Ve-térinaires, INRA Publ. Paris 1982. Les colloques de 1’I.N.R.A., 8, 133–134.
Gyrd-Hansen, N., F. Rasmussen & M. Smith: Cardiovascular effects of intravenous administration of tetracycline in cattle. J. vet. Pharmacol. Therap. 1981, 4, 15–25.
Hjerpe, C. A.: Treatment of bacterial pneumonia in feedlot cattle. Proc. Annu. Meet. Amer. Ass. Bovine Pract. 1975, 8, 33–47.
Kunin, C. M., A. C. Dornbusch Sc M. Finland: Distribution and excretion of four tetracycline analogues in normal young men. J. clin. Invest. 1959, 38, 1950–1963.
Luthman, J. & S.-O. Jacobsson: A comparison of two oxytetracycline formulations in cattle. Acta vet. scand. 1982, 23, 147–149.
Mercer, H. D., R. H. Teske, P. E. Long & D. H. Showalter: Drug residues in food animals. II. Plasma and tissue kinetics of oxytetracycline in young cross-bred swine. J. vet. Pharmacol. Therap. 1978, 1, 119–128.
Nouws, J. F. M.: Comparative plasma oxytetracycline levels of a “long acting” and a normal oxytetracycline formulation in ruminant calves. Pharmacologic et Toxicologic Vétérinaires, INRA Publ. Paris 1982. Les collogues de l’I.N.R.A., 8, 195–198.
Poiger, H. & C. Schlatter: Fluorimetric determination of tetracyclines in biological materials. Analyst 1976, 101, 808–814.
Schipper, L A. Sc W. E. Petersen: Milk, blood and urine concentrations of aureomycin after intramammary infusions and intravenous administration. Vet. Med. 1952, 47, 367–371.
Sedman, A. J. & J. G. Wagner: AUTOAN. A decision-making computer program. Publication Distribution Service. Ann Arbor, Michigan 1976.
Simpson, J. E.: Sustained oxytetracycline blood concentrations in swine due to a unique long-acting formulation. Proc, Internat. Pig Vet. Soc, 5th World Congress, Zagreb 1978, M 46.
Xia, W., N. Gyrd-Hansen & P. Nielsen: Comparison of pharmacokinetic parameters for two oxytetracycline preparations in pigs. In press.
Yoder, H. W. & R. A. Packer: Bovine blood serum concentrations of terramycin (oxytetracycline) following intravenous and intramuscular administration. Amer. J. vet. Res. 1954, 15, 412–416.
Ziv, G. & F. G. Sulman: Analysis of pharmacokinetic properties of nine tetracycline analoques in dairy cows and ewes. Amer. J. vet. Res. 1974, 35, 1197–1201.
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Xia, W., Nielsen, P. & Gyrd-Hansen, N. Oxytetragyclines in Cattle. Acta Vet Scand 24, 120–128 (1983). https://doi.org/10.1186/BF03546763
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DOI: https://doi.org/10.1186/BF03546763