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Colostral Transfer in the Goat of Antibodies Against Corynebacterium Pseudotuberculosis and the Antibody Status of Kids During the First 10 Months of Life
Overføring av antistoffer mot Coryneb acterium pseudotuberculosis fra geiter til kje og antistoff status hos kje de første 10 levemåneder.
Acta Veterinaria Scandinavica volume 23, pages 483–489 (1982)
Abstract
Serum and colostrum samples from goats at parturition and serum samples from their kids at 3 days and at 4, 7, 10 and 12 weeks after birth were examined for the presence of antibodies to Corynebacterium pseudotuberculosis hemolysins. The hemolysis inhibition test (HIT) was used. High correlation was found between titre values of antihemolysins in serum and colostrum of goats at parturition (correlation coefficient r = 0.83; P < 0.01). Intermediate correlation was found between antihemolysin titre in colostrum of goats and in the sera of their kids 3 days old (r = 0.56; 0.01 < P < 0.05). Furthermore, titre values for 3 day-old kids showed high correlation with the antihemolysin titres when the kids aged 4 and 7 weeks (r = 0.76 and 0.85, respectively; P < 0.01). Antihemolysin titres decreased linearly in kids from 3 days to 10 weeks old. Calculated half life of antibodies was 12 days. Most of the kids had detectable antibodies up to the age of 5–6 weeks. None of the kids were seropositive at 2½ months of age.
Serum samples collected monthly from a group of kids chosen at random, aged 7–10 months, contained antibodies to hemolysins in half of the animals at the first testing. At the age of 10 months 14 out of 15 kids were seropositive. Thus, most of the kids from this herd were exposed to G. pseudotuberculosis antigens during summer and autumn of their first year of life.
Prophylactic measures against caseous lymphadenitis is briefly discussed.
Sammendrag
Serum- og kolostrum-prøver fra geiter ved partus og serumprøver fra deres kje 3 dager, 4, 7, 10 og 12 uker etter fødsel ble undersøkt ved bruk av antihemolysintest (AHT) for antistoffer mot Corynebac-terium pseudotuberculosis hemolysiner. Det var høg korrelasjon mel-lom titerverdiene a ν antihemolysiner i serum og kolostrum hos geitene (r = 0,83; Ρ < 0,01), og middels høg korrelasjon mellom antihemo-lysintiter i kolostrum hos geitene og i serum hos deres 3 dager gamle kje (r = 0,56; 0,01 < Ρ < 0,05). Titerverdiene hos 3 dager gamle kje viste videre en høg korrelasjon med serumtiteret hos kjeene ved 4 og 7 ukers alder (henholdsvis r = 0,76 og 0,85; Ρ < 0,01). Titerverdiene av antihemolysiner avtok linsert hos kje i alderen 3 dager til 10 uker. Halveringstiden ble utregnet til 12 dager. Storparten av kjeene hadde positive titerverdier fram til 5–6 ukers alder. Ved 2½ måneders alder var ingen kje seropositive.
Ved undersøkeLse aν en gruppe kje i alderen 7–10 mane der, ble det påvist antihemolysiner hos halvparten av dyra ved første prøve-uttak. Ved 10 måneders alder var 14 av 15 kje seropositive. De fleste kjeene fra den undersøkte besetningen fikk således antigen kontakt med C. pseudotuberculosis i løpet av sommeren og høsten første leveår.
Tidsrom for iverksetting av eventuelle profylaktiske tiltak mot kaseøs lymfadenitt ble kort drøftet.
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This study was supported by grants from the Agricultural Research Council of Norway.
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Lund, A., Almlid, T., Steine, T. et al. Colostral Transfer in the Goat of Antibodies Against Corynebacterium Pseudotuberculosis and the Antibody Status of Kids During the First 10 Months of Life. Acta Vet Scand 23, 483–489 (1982). https://doi.org/10.1186/BF03546767
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DOI: https://doi.org/10.1186/BF03546767