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The Diagnosis of Pancreatic Degenerative Atrophy in Dogs – a Practical Method

En praktisk metod att diagnostisera bukspottkörtelns atrofi hos hund

Abstract

A convenient method was developed to diagnose pancreatic degenerative atrophy (PDA) in small animal practice based on the observations, that feeding crude soybean increases faecal protease activity in dogs with normal pancreatic function, while PDA-dogs remain completely negative in faecal protease activity.

When PDA is suspected, 1 or 2 faecal samples should be investigated with the X-ray film method based on incubation for 2 h at 37°G. If any activity is seen the dog should be considered non-PDA. If no activity is seen the dog should be given food supplemented with 1 g crude soybean/kg body weight twice daily for a few days and a new faecal sample should be collected. If the activity remains negative the diagnosis of PDA is reliable.

As the amount of crude soybean in the food increased, a dose dependent increase of faecal protease and amylase was seen as measured with the radial enzyme diffusion method (RED).

Sammendrag

En behändig metod att diagnostisera degenerativ atrofi i bukspottskörteln inom ramen for vanlig smådjurspraktik har utvecklats.

Metoden baserar sig på Observationen att när hundar med normal funktion i bukspottskörteln matas med rå soja, sa ökar proteas aktiviteten i avföringen, men PDA-hundarnas proteas aktivitet i avföringen förblev fultständigt negativ.

När PDA misstänks, skall en eller två avföringsprov undersökas med rtg-film metoden med inkubationstiden två timmar i 37 °C. Om aktivitet kan konstateras, kan hunden anses vara en ej-PDA hund. Om däremot ingen aktivitet kan konstateras, bör hundens mat kompleteras med 1 g rå soja/kg kroppsvikt två gånger dagligen under några dagar, varefter nya avföringsprov tas. Om aktiviteten fortfarande är negativ, kan diagnosen PDA anses vara pålitlig.

När mängden av rå soja ökades i maten, steg proteas och amylas avtiviteten i avföringen vid mätning med radial entzym diffusion (RED).

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Westermarck, E. The Diagnosis of Pancreatic Degenerative Atrophy in Dogs – a Practical Method. Acta Vet Scand 23, 197–203 (1982). https://doi.org/10.1186/BF03546805

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