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Excretion of Methoxychlor in Cow Milk Following Dermal Application
Utskillelse av metoksyklor i kumelk etter dermal applikasjon
Acta Veterinaria Scandinavica volume 23, pages 16–23 (1982)
Abstract
The concentrations of methoxychlor in cow milk and plasma were determined following a cutaneous application of a non-commercial emulsion and an intravenous injection of a solution containing 5 and 1 g methoxychlor, respectively. Furthermore, some pharmacokinetic parameters were estimated and the results were evaluated toxicologically by comparison with the acceptable daily intake.
Maximum concentration of methoxychlor in milk, found 2 days after dermal administration, was 0.062 ppm, decreasing to around 0.005 ppm 30 days later.
From the results, a distribution volume greater than 200 times the body volume, a dermal absorption of around 1/5 of the topically applicated dose, and a half-life of 8–10 days were estimated.
It was concluded that the levels in cow milk, following dermal application with an emulsion of methoxychlor did not represent any threat to human health and methoxychlor was recommended as a pesticide of choice for use on dairy cows.
Sammendrag
Metoksyklor-nivå i kumelk og plasma ble besternt etter dermal applikasjon av en ikke-kammersiell emulsjon og en intravenøs injeksjon av en løsning inneholdende henholdsvis 5 og 1 g metoksyklor. Videre ble noen farmakokinetiske parametre forsøkt besternt og resultatene ble evaluert toksikologisk ved sammenligning med det akseptable daglige inntak (ADI-verdi) (WHO/FAO 1978).
Maksimumsverdier av metoksyklor i melk var 0.052 ppm 2 dager etter dermal applikasjon. Nivået var ca 0.005 ppm etter 30 dager.
Distribusjonsvolumet ble estimert større enn 200 ganger kroppsvolumet, den dermale absorpsjon ca 1/5 av applisert dose og halveringstiden 8–10 dager.
Det ble konkludert med at nivåene i kumelk etter dermal applikasjon av en metoksyklor emulsjon ikke representerer noen helserisiko og metoksyklor kan anbefales som et pesticid til bruk på melkekuer.
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Skaare, J.U., Berge, G., Ødegaard, S. et al. Excretion of Methoxychlor in Cow Milk Following Dermal Application. Acta Vet Scand 23, 16–23 (1982). https://doi.org/10.1186/BF03546817
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DOI: https://doi.org/10.1186/BF03546817