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The Effect of Endotoxin on the Liver Lipid Peroxide Level and on the Liver and Plasma Zinc Concentrations in Rats As Related to Time After Administration

Effekten au endotoxin på leverns lipidperoxidnivå och på koncentrationen au zink i teuer och plasma hos råtta som en funktion au tiden efter endotoxinbehandlingen

Acta Veterinaria Scandinavica volume 23, pages 24–29 (1982)Cite this article

Abstract

The lipid peroxide level of rat liver increased due to i.p. endotoxin injection, reaching its maximum, value 24 h after administration. After that the level declined, reaching approximately the initial value at 48 h. The liver Zn concentration increased and the plasma Zn concentration rapidly decreased after the injection. The liver Zn concentration then gradually declined and the plasma Zn respectively increased near the initial level 48 h after the injection.

The highest lipid peroxide level occurred at 24 h when the mean Zn concentration of the plasma and liver were already relatively near the initial level, suggesting a regulative role of Zn in lipid peroxidation.

Sammandrag

Leverns lipidperoxidnivå på råtta steg efter intraperitoneal endo-toxin-injektion ocr nådde maximalvärdet 24 timmar efter injektionen. Därefter sjönk värdet och var ungefär på ursprungsnivån efter 48 timmar. Leverns Zn koncentration steg och plasmans Zn koncentration minskade hastigt efter injektionen. Senare sjönk leverns Zn koncentration gradvis och plasmans Zn koncentration steg på motsvarande sätt. Båda koncentrationerna var vid ursprungsnivån ca 48 timmar efter injektkionen. Den högsta lipidperoxidnivån nåddes när den genomsnittliga koncentrationen av Zn i plasma och lever redan hade stigit resp. sjunkit till närheten av initialvärdet före behandlingen. Detta antyder att Zn möjligen har en regulerande roll i lipidperoxidationen.

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Authors and Affiliations

  1. Department of Biochemistry and the Department of Food Hygiene, College of Veterinary Medicine, P. O. Box 6, Helsinki 55, Helsinki, SF-00551, Finland

    Satu Sankari & Timo Pekkanen

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  1. Satu Sankari
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  2. Timo Pekkanen
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Sankari, S., Pekkanen, T. The Effect of Endotoxin on the Liver Lipid Peroxide Level and on the Liver and Plasma Zinc Concentrations in Rats As Related to Time After Administration. Acta Vet Scand 23, 24–29 (1982). https://doi.org/10.1186/BF03546818

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Acta Veterinaria Scandinavica

ISSN: 1751-0147