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Experimental Post-Traumatic Lung Insufficiency in Dogs
Eksperimentell post-traumatisk lungesvikt hos hund. Makrcskopiske og lysmikroskopiske lungeforandringer.
Gross and Light Microscopic Lung Lesions
Acta Veterinaria Scandinavica volume 23, pages 118–127 (1982)
Abstract
Post-traumatic lung insufficiency in dogs was induced by a combination of haemorrhagic hypotension and liver trauma. In one experimental group, lung biopsies were sampled every 4 h. This paper describes the development of gross and light microscopic lunig changes in these dogs, and the lung lesions 12 h after initiation of the trauma in another experimental group. Incipient changes were recognized as early as 4 h after initiation of the trauma. Perivascular and intraseptal oedema, scattered microthrombi, and trapping of leucocytes in lung microvessels were the most conspicuous morphological findings. These changes grew gradually more pronounced towards collapse, when also areas with interstitial haemorrhages, intra-alveolar protein-rich oedema fluid with strands of a fibrinoid material, and an increased number of partly degenerated leucocytes were found in addition to atelectasis.
The morphological lung lesions in this experimental model are similar to post-traumatic shock lungs in human patients.
Sammendrag
En kombinasjon av blødningshypotensjon og leverskade ble be-nyttet for å framkalle post-traumatisk lungesvikt hos hund. I en for-søksgruppe ble det tatt biopsier hver 4. time. Denne artikkelen beskri-ver utviklingen av makroskopiske og lysmikroskopiske lungeforandringer hos disse hundene. Dessuten beskrives lungeforandringene 12 timer etter initiering av leverskaden i en annen forsøksgruppe. Morfo-logiske forandringer i lungene ble observert allerede etter 4 timer. De mest framtredende forandringene var ødem i alveolesepta og i binde-vevet rundt kar, spredte hyaline mikrotromber og ansamlinger av polymorfkjernede leukocytter i små lungekar. Forandringene ble grad-vis mer uttalte fram mot kollaps, da det i tillegg såes interstitielle blødninger, proteinrik ødemvæske med fibrinoid materiale og økt an-tall, delvis degenererte leukocytter i lumen av alveolene. Det var dessuten betydelig atelektase ved kollaps.
Det foreliggende arbeidet viser at en kombinasjon av hypotensjon og leverskade hos hund resulterer i lungeforandringer som i stor grad ligner post-traumatisk sjokklunge slik den beskrives hos menneske. Den patogenetiske betydning interstitiell og alveolsert ødem, mikrotromber og leukocyttaggregering har for utvikling av „sjokklunge” diskuteres.
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This work was supported by grants from the Agricultural Research Council of Norway, and Jahre’s Foundation.
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Lium, B., Saugstad, O.D., Aasen, A.O. et al. Experimental Post-Traumatic Lung Insufficiency in Dogs. Acta Vet Scand 23, 118–127 (1982). https://doi.org/10.1186/BF03546828
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DOI: https://doi.org/10.1186/BF03546828