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Plasma Levels of Immunoreactive Parathyroid Hormone in Relation to Starvation Hypocalgaemia in Dairy Cows

Hypokalsemi hos melkekyr utløst ued faste

Acta Veterinaria Scandinavica volume 21, pages 457–467 (1980)Cite this article

Abstract

The hypocalcaemia caused by parturition and onset of lactation in high-production dairy cows was mimicked by subjecting cows to starvation periods before and after partus. The changes in plasma calcium, phosphate and magnesium were followed and compared with immunoreactive parathyroid hormone (iPTH) in 2 cows. During the starvation periods before partus, the cows developed hypocalcaemia with no or only small changes in the plasma concentration of magnesium. After the onset of hypocalcaemia, the concentration of iPTH increased on the average 3–4-fold and the raised hormone levels lasted about 24 h after start of refeeding. An increase in plasma phosphate occurred somewhat later than the rise in iPTH and lasted longer. After partus hypocalcaemia developed, together with smaller increases in iPTH concentration (about 2-fold). The post-partum starvation period again resulted in hypocalcaemia and raised iPTH concentrations.

In conclusion, starvation and parturition induced inverse changes in plasma calcium and iPTH in dairy cows. The increases in plasma iPTH were reversible and considered secondary to the hypocalcaemia. Through the effect of paratyroid hormone, plasma calcium was normalized and phosphate concentration increased. Therefore, fatal hypocalcaemia which may occur following the course of parturition and onset of lactation is not due to impaired PTH secretion.

Sammendrag

Konsentrasjonen av parathormon (PTH), kalsium, magnesium og uorganisk fosfat ble mlt i plasma hos 2 melkekyr i forbindelse med kalving og under innlagte fasteperioder.

I forbindelse med kalving økte konsentrasjonen av plasma PTH sekundært til en reduksjon i plasma kalsium konsentrasjonen. Parallelle, men mer uttalte forandringer i PTH og kalsium, ble mlt under fasteperioder.

Forandringer i konsentrasjonen av magnesium og uorganisk fosfat under kalving var varierende. Under fasteperioderne var det imidlertid et fall i plasma magnesium og en bifasisk økning i plasma fosfat.

Resultatene viser at melkefeber hos kyr ikke skyldes en primaer svikt i parathormon produksjon.

References

  • Arnaud, C. D., H. S. Tsao & T. Littledyke: Radioimmunoassay of human parathyroid hormone in serum. J. clin. Invest. 1971, 50, 21 –34.

  • Boda, J. M. & H. H. Cole: The influence of dietary calcium, and phosphorus on the incidence of milk fever in dairy cattle. J. Dairy Sci. 1954, 37, 360.

    Article  CAS  Google Scholar 

  • Capen, C. C. & D. M. Young: Thyrocalcitonin – Evidence for release in a spontaneous hypocalcaemic disorder. Science 1967, 157, 205–206.

    Article  CAS  Google Scholar 

  • Dryerre, H. & J. R. Grieg: Milk Fever: Its possible association with derangements in internal secretions. Vet. Rec. 1925, 5, 225–231.

    Google Scholar 

  • Gautvik, K. M., V. Teig, J. F. Halvorsen, E. Arnesen, L. Myhre, P. Heimann & R. Tollman: Development of a sequence specific radioimmunoassay for human parathyroid hormone and its use in the diagnosis of hyper-parathyroidism. Scand. J. clin. Lab. Invest. 1979, 39, 469–478.

    Article  CAS  Google Scholar 

  • Halse, K.: Apparent strengthening of calcium homeostasis in cows by starvation of short duration. Nord. Vet.-Med. 1958, 10, 9–16.

    Google Scholar 

  • Halse, K.: Individual variation in blood magnesium and susceptibility to hypomagnesaemia in cows. Acta vet. scand. 1970, 11, 394–414.

    Article  CAS  Google Scholar 

  • Kronfeld, D. S.: Parturient hypocalcaemia in dairy cows. Advanc. vet. Sci. 1971, 15, 133–157.

    CAS  Google Scholar 

  • Kronfeld, D. S. & C. F. Romberg Jr.: The mammary drain of calcium. In Parturient Hypocalcaemia, J. J. B. Andersen, ed. Acad. Press, New York 1970, 107 pp.

  • Littledyke, E. T.: Relationship of milk secretion to hypocalcaemia in the dairy cow. J. Dairy Sci. 1976, 59, 1947–1953.

    Article  Google Scholar 

  • Marshak, R. R.: Recent aetiological considerations in milk fever. Univ. Pennsylvania Bull., Veterinary Extension Quarterly 1957, No. 146, p. 104–118.

  • Mayer, G. P.: The role of parathyroid hormone and thyrocalcitonin in parturient paresis. In Parturient Hypocalcaemia. J. J. B. Andersen, ed. Acad. Press, New York 1970, 107 pp.

  • Mayer, G. P., C. F. Ramberg Jr., D. S. Kronfeld, R. M. Buckle, L. M. Sherwood, G. D. Hurback & J. T. Potts Jr.: Plasma parathyroid hormone concentrations in hypocalcaemic dairy cows. Amer. J. vet. Res. 1969, 30, 1587–1597.

    CAS  PubMed  Google Scholar 

  • Rasmussen, H.: Hormonal control of bone cell function. Triangle (En.) 1973, 12, 103–109.

    CAS  Google Scholar 

  • Rasmussen, H. & P. Bordier: In The Physiological and Cellular Basis of Metabolic Bone Disease. H. Rasmussen & P. Bordier, ed. Williams and Wilkins, Baltimore 1974.

  • Sherwood, L. M., J. T. Potts Jr., A. D. Care, G. P. Mayer & G. D. Aurbach: Evaluation by radioimmunoassay of factors controlling the secretion of parathyroid hormone. Nature (Lond.) 1966, 209, 52–55.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, Veterinary College of Norway, the Institute for Surgical Research, Rikshospitalet, P. O. Box 8146, Dep., Oslo 1, Oslo, Norway

    Richard L. Tollman & Kaare M. Gautvik

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  1. Richard L. Tollman
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  2. Kaare M. Gautvik
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This work was financially supported by a scholarship grant provided by the Norwegian Agricultural Research Council.

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Tollman, R.L., Gautvik, K.M. Plasma Levels of Immunoreactive Parathyroid Hormone in Relation to Starvation Hypocalgaemia in Dairy Cows. Acta Vet Scand 21, 457–467 (1980). https://doi.org/10.1186/BF03546834

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Acta Veterinaria Scandinavica

ISSN: 1751-0147