Skip to main content
  • Published:

Concentration of Serum Prealbumin (Pr) Protein in Sick Horses and Its Correlation to Blood Leucocyte Count and Albumin Content in Serum

Konsentrasjon av prealbumin (Pr) protein i serum hos syke bester og dets korrelasjon til antall leucocyter i blod og albumininnhold i serum

Abstract

Studies of Pr protein concentrations in sera of sick horses were carried out using Mancini et al.’s (1965) immunodiffusion technique. Relative values against a chosen standard of 100 % were determined for a total of 102 horses. Horses with acute infections had Pr protein values significantly above the normal. The highest individual Pr protein value recorded in this group was 202. Horses suffering from acute laminitis and malignant tumours also had increased Pr protein values.

There was a positive correlation between the Pr protein value and the blood leucocyte count and a negative correlation between the Pr protein value and the albumin content in serum.

Sammendrag

Det ble foretatt en undersøkelse av Pr protein-konsentrasjonene i sera fra syke hester ved hjelp av Mancini et al.’s (1965) immundiffusjons-teknikk. Relative verdier i forhold til en valgt standard p 100 % ble besternt p et totalantall p 102 hester. Hester med akutte infeksjoner hadde Pr protein verdier som var signifikant høyere enn normale dyr. Den høyeste individuelle verdi som ble registrert i denne gruppen var 202. Hester med akutt forfangenhet og maligne svulster hadde også forhøyede Pr protein verdier i forhold til normale dyr.

Det var en positiv korrelasjon mellom Pr protein verdien i serum og antallet leucocyter i blodet og en negativ korrelasjon mellom Pr protein verdien og albumininnholdet i serum.

References

  • Breeze, E. G., J. M. Nicholls, J. Veitch, G. E. Seltnem, E. A. Mc Pherson & G. K. H. Lawson: Serum antitrypsin activity in horses with chronic pulmonary disease. Vet. Rec. 1977, 101, 146–149.

    Article  CAS  Google Scholar 

  • Brsend, M.: Genetics of horse acidic prealbumins. Genetics 1970, 65, 495–503.

    Article  Google Scholar 

  • Corbella, E.: First results of quantitative protease-inhibitors evaluation in equine pathology. Atti Soc. Ital. Sci. vet. 1975, 29, 315–318.

    Google Scholar 

  • Dimopoullos, G. T.: Plasma proteins. In Clinical Biochemistry of Domestic Animals. 2nd Ed., J. J. Kaneko & C.. E. Cornelius, eds. Acad. Press, New York and London 1970.

  • Ek, N.: Studies of electrophoresis on cellulose acetate membrane of serum proteins from normal horses, sheep and pigs. Acta vet. scand. 1970, 11, 295–304.

    Article  CAS  Google Scholar 

  • Ek, N. & M. Brsend: Quantitative comparisons of acidic prealbumin (Pr) phenotypes in horses. Acta vet. scand. 1980, 21, 380–388.

    Article  CAS  Google Scholar 

  • Ganrot, P. O., C.-B. Laurell Sc S. Eriksson: Obstructive lung disease and trypsin inhibitors in α1-antitrypsin deficiency. Scand. J. clin. Lab. Invest. 1967, 19, 205–208.

    Article  CAS  Google Scholar 

  • Harris, C. C., A. Primack & M. H. Cohen: Elevated alpha-1-antitrypsin levels in lung cancer patients. Cancer (Philad.) 1974, 34, 280–281.

  • Kueppers, F.: Genetically determined differences in the response of alpha-antitrypsin levels in human serum to typhoid vaccine. Hum. Genet. 1968, 6, 207–214.

    Article  CAS  Google Scholar 

  • Mancini, G., A. O. Carbonara & J. F. Heremans: Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 1965, 2, 235–254.

    Article  CAS  Google Scholar 

  • Ohlson, K.: Neutral leucocyte proteases and elastase inhibited by plasma alpha-/-antitrypsin. Scand. J. clin. Lab. Invest. 1971, 28, 251–253.

    Article  Google Scholar 

  • Schalm, O. W.: Veterinary Hematology. Lea & Febiger, Philadelphia 1967.

  • Snedecor, G. W. & W. G. Cochran: Statistical Methods. Iowa State Univ. Press, Ames, Iowa, USA 1967.

  • Thorèn-Tolling, K.: Serum protein variations with pathologic conditions by horses and dogs. Svensk Vet.-Tidn. 1977, 20, 917–927.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ek, N. Concentration of Serum Prealbumin (Pr) Protein in Sick Horses and Its Correlation to Blood Leucocyte Count and Albumin Content in Serum. Acta Vet Scand 21, 482–497 (1980). https://doi.org/10.1186/BF03546836

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1186/BF03546836

Keywords