Skip to main content
Download PDF
  • Published:

Variation of type Antigens of Group-B Streptococci

Variation of gruppe B-streptokok typeantigener. I. Variation af X-antigenet og andre typeantigener i besætninger hvor X-antigenet forekommer. Gruppe B-streptokokker (B-str.), hvor proteinantigenet X kunne påvises, forekom i 56 af 129 besætninger, hvor B-str. infektion diagnosticeredes i perioden 1/4 1976 – 1/4 1979

I. Variation of the X-Antigen and of other type Antigens in Herds Where the X-Antigen Occurs

Acta Veterinaria Scandinavica volume 21, pages 367–374 (1980)Cite this article

Abstract

Serological typing of Group-B streptococci isolated on different occasions during the course of natural intramammary infections revealed no shifts between polysaccharide types, but showed that polysaccharide antigens and the protein Ibc antigen may be lost and regained. Pure X-strains may arise from strains previously typed as IIIX or III, or from non-typeable strains, and possibly from Ibc, Ia and Ib strains as well. Such strains may later revert to their original types.

Sammendrag

Typebestemmelsesresultater fra 16 af “X-besaetningerne” analyseredes nøjere med henblik på påvisning af art ag hyppighed af antigenvariation.

I de 16 besætninger, der kunne opdeles i 4 kategorier (Tabel 1), fandtes 588 B-str. inficerede kirtler.

Retypisering (= gentagen typebestemmelse, når en kirtel viste sig fortsat inficeret ved en senere besætningsundersøgelse) blev foretaget for isolater fra 209 kirtler; 123 af disse udskilte fortsat B-str. af samme type, medens 86 kirtler viste typeskift ved retypisering. For de 86 varierende kirtler forelå ialt 149 typebestemmelser. To på hinanden følgende undersøgelser viste samme type i 46 tilfælde, medens 103 viste variation. Tretten kirtler reverterede efter variation til den oprindelige type. Fire kirtler udskilte B-str. af 3 typer.

Variationernes art, antal og udbredelse fremgår af Tabel 2. Variationen III⇆IIIX var hyppigst forekommende (51/103) og mest udbredt (9/16).

Tab af polysakkaridantigen III sås i 5 besætninger i ialt 17 tilfaelde, og omvendt kunne isolater fra X eller NT kirtler (4) ved senere undersøgelse vise sig at have III antigenet. Variationen X⇆NT var almindelig (19/103). Andre antigenvariationer forekom sjaeldent (se Tabel 2) i dette materiale,

Undersøgelsen viste, at der ikke sker skift mellem polysakkaridtyper, men at såvel polysakkaridantigener som Ibc proteinantigenet er variabelt. X-stammer kan hidrøre fra stammer tidligere typebestemt til IIIX, III eller NT og antagelig også fra Ibc, Ia og Ib stammer.

Det konkluderes, at påvisning af B-str. af fiere typer i en besætning ikke umiddelbart viser, at en sådan besætning er blevet inficeret fra forskellige kilder.

References

  • Jelinkova, J.: Group B streptococci in the human population. Gurr Top. Microbiol. Immunol. 1977, 76, 127–165.

    Google Scholar 

  • Jensen, N. E.: Forgseringstyper af gruppe B-streptokokker. (Biochemi cal types of Group-B streptococci). Nord. Vet.-Med. 1976, 28 434–444.

  • Jensen, N. E.: Production and evaluation of antisera for serological type determination of Group-B streptococci by double diffusion in agarose gel. Acta path, microbiol. scand. Sect. B. 1979, 87, 77–83.

  • ensen, N. E.: Distribution of serotypes of Group-B streptococci in herds and cows within an area of Denmark. Acta vet. scand. 1980a, 21, 354–366.

    Google Scholar 

  • Jensen, N. E.: Serotypes of Group-B streptococci in urogenital patients. Scand. J. infect. Dis. 1980b, 12, 101–104.

    Article  CAS  Google Scholar 

  • Lancefield, R. C.: A serological differentiation of specific types of bovine hemolytic streptococci (Group B). J. exp. Med. 1934, 59, 441–458.

    Article  CAS  Google Scholar 

  • Lancefield, R. C.: Two serological types of Group B hemolytic streptococci with related, but not identical, type-specific substances. J. exp. Med. 1938, 67, 25–40.

    Article  CAS  Google Scholar 

  • Lancefield, R. C.: Cellular antigens of Group B streptococci. In: L. W. Wannamaker and J. M. Matsen, eds.: Streptococci and Streptococcal Diseases. Acad. Press, New York and London 1972, 57–64.

  • Lancefield, R. C., M. Mac Carty & W. N. Everly: Multiple mouse-protective antibodies directed against Group B streptococci. J. exp. Med. 1975, 142, 165–179.

    Article  CAS  Google Scholar 

  • Müller, G.: Die Typisierung der Streptokokken der Gruppe B. III. Mitteilung: Die Verteilung der Typen des Sc. agalactiae in den Rinderbeständen des Bezirkes Gera. (The typing of Group-B Streptococci. III. Communication: The distribution of types of Str. agalactiae among herds in the area of Gera). Arch. exp. Vet-Med. 1967, 21, 65–76.

    Google Scholar 

  • Pattison, I. H., P. JR. J. Matthews & W. R. Maxted: Type classification by Lancefield’s precipitin method of human and bovine Group B streptococci isolated in Britain. J. Path. Bact. 1955a, 69, 43–50.

    Article  CAS  Google Scholar 

  • Pattison, L H., P. R. J. Matthews & D. G. Howell: The type classification of Group B streptococci with special reference to bovine strains apparently lacking in type polysaccharide. J. Path. Bact. 1955b, 69, 51–60.

    Article  CAS  Google Scholar 

  • Stableforth, A. W.: The incidence of the various serological types of Str. agalactiae in herds of cows in Great Britain. J. Path. 1938, 46, 21–29.

  • Wilkinson, H. W.: Immunochemistry of purified polysaccharide type antigens of Group B streptococcal Types Ia, Ib and Ic. Infect. Immun. 1975, 11, 845–852.

    Article  CAS  Google Scholar 

  • Wilkinson, H. W.: Nontypeable Group B streptococci isolated from human sources. J. clin. Microbiol. 1977, 6, 183–184.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wilkinson, H. W. & R. G. Eagon: Type specific antigens of Group B Type Ic streptococci. Infect. Immun. 1971, 4, 596–604.

  • Wilkinson, H. W. & M. D. Moody: Serological relationships of Type I antigens of Group B. streptococci. J. Bact. 1969, 97, 629–634.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State Veterinary Serum Laboratory, Odinsvej 4, Ringsted, DK-4100, Denmark

    Niels Einar Jensen

Authors
  1. Niels Einar Jensen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jensen, N.E. Variation of type Antigens of Group-B Streptococci. Acta Vet Scand 21, 367–374 (1980). https://doi.org/10.1186/BF03546868

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1186/BF03546868

Keywords

Acta Veterinaria Scandinavica

ISSN: 1751-0147