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Listeriosis in Sheep

Listeriose hos sau. Eksperimentell infeksjon med Listeria monocytogenes hos sauer behandla med ulika immunosuppressiva

Experimental Listeric Infection in Sheep Treated with Various Immunosuppressiva

Acta Veterinaria Scandinavica volume 21, pages 415–427 (1980)Cite this article

Abstract

Four groups of lambs, about 6 months old, were given 4 different immunosuppressiva (prednisolone, cyclophosphamide, niridazole and gestagene hormones), 1 substance to each group. After this treatment the 4 groups together with a 5th group of the same size, were infected with Listeria monocytogenes (Lm).

None of the animals developed clinical listeric encephalitis. The level of antibodies differed between the groups. The group not given any immun osuppressivum reached the highest antibody titres, the group given gestagene hormones had the lowest titres and the other groups ranged somewhere inbetween. All the groups except the group treated with niridazole had a strong delayed hypersensitivity reaction against Lm. The effects of the treatment upon some blood components are also described.

Further studies are necessary to establish the effect of various immunosuppressiva, especially gestagene hormones.

Sammendrag

Fire grupper av 6 månader garnie lam blei behandla med 4 ulike immunosuppressiva (prednisolon, cyclophosphamate, niridazol, geslagene hormon). Etter behandling blei dei 4 gruppene saman med ei tilsvarande femte ubehandla gruppe infiserte med Listeria monocytogenes (Lm).

Ingen av dyra fekk typisk listeria-encefalitt. Gruppene utvikla ulike nivå av antistoff mot Lm. Mest antistoff blei funne i den gruppa som ikkje hadde fått immunosuppressiva, og minst i den gruppa som hadde fått geslagene hormon. Nivået i dei andre gruppene låg ein stad meilom desse. Alle gruppene utanom den gruppa som hadde fått niridazol viste ein sterk seinka hypersensitivitetsreaksjon mot Lm. Eit oversyn over verknaden på ulike blodkomponentar er og gjeve.

Forsøket synte at vidare studier trengst for å finna meir ut om korleis ulike immunosuppressiva, og sserleg då gestagene hormon, verkar på immuniteten mot mikroorganismar.

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Authors and Affiliations

  1. State Veterinary Research Station for Small Ruminants, Postboks 248, Hoyland, Sandnes, 4301, Norway

    Hallstein Grønstøl

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  1. Hallstein Grønstøl
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This work was supported by grants from the Norwegian Agricultural Research Council.

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Grønstøl, H. Listeriosis in Sheep. Acta Vet Scand 21, 415–427 (1980). https://doi.org/10.1186/BF03546874

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Keywords

Acta Veterinaria Scandinavica

ISSN: 1751-0147