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Anemia and Growth Retardation in Totally Gastrectomized Swine

Anæmi og hæmmet tilvækst hos totalt gastrektomerede svin.

Acta Veterinaria Scandinavica volume 21, pages 197–208 (1980)Cite this article

Abstract

The effects of total gastrectomy in six young swine were followed and described during an experimental period up to 18 months. Two of the gastrectomized pigs (Nos. 1 and 2) were medicated with cycobemin every second week. Two other gastrectomized pigs (Nos. 11 and 14) were medicated with iron-dextran twice a week. Three non-gastrectomized swine receiving the same feed as the gastrectomized animals were observed as controls for up to eight months.

One of the gastrectomized non-medicated pigs (No. 4) did not gain weight, while the other gastrectomized animals had a normal appearance and gained weight but less than the controls. The non-medicated as well as the cycobemin-medicated gastrectomized animals developed a microcytic hypochrome anemia corresponding to the anemia in iron deficiency. Histochemically loss of iron in the depots (liver, spleen, bone marrow and intestine) was demonstrated in the gastrectomized animals except those treated with iron-dextran. Histological and histochemical examinations of the nervous system did not show any abnormalities.

Sammendrag

Virkningen af total gastrektomi af 6 pattegrise blev undersøgt og beskrevet over en forsøgsperiode på op til 18 måneder. To af de gastrektomerede svin (nr. 1 og 2) blev behandlet med cycobemin hver anden uge og 2 andre (nr. 11 og 14) blev behandlet med jern-dextran 2 gange pr. uge. Tre ikke-gastrektomerede svin fungerede som kontroldyr og fik samme foder som de gastrektomerede svin. Kontroldyrene blev observeret i op til 8 måneder.

Ét af de gastrektomerede, ubehandlede svin (nr. 4) tog ikke på i vægt. De øvrige gastrektomerede svin var normale af udseende og tog på i vægt, men tilvæksten var mindre end hos kontroldyrene. Både de cycobeminbehandlede og de ubehandlede gastrektomerede svin udviklede en mikrocytser hypokrom ansemi svarende til en jernmangel anaemi. Ved histokemisk undersøgelse påvistes tab af jern fra depoterne (lever, milt, knoglemarv og tarm) hos alle gastrektomerede dyr, som ikke var blevet behandlet med jern-dextran. Ved de gennemførte histologiske og histokemiske undersøgelser af nervesystemet kunne der ikke påvises forandringer i vævene.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Royal Veterinary and Agricultural University, and the Geriatric Centre („De garnies By”), Copenhagen, Denmark, USA

    Svend Petri, Folke Rasmussen & Claus Petri

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  1. Svend Petri
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  2. Folke Rasmussen
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  3. Claus Petri
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Financially aided by a grant from the P. Carl Petersen Foundation.

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Petri, S., Rasmussen, F. & Petri, C. Anemia and Growth Retardation in Totally Gastrectomized Swine. Acta Vet Scand 21, 197–208 (1980). https://doi.org/10.1186/BF03546883

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Acta Veterinaria Scandinavica

ISSN: 1751-0147