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Effects of Transportations, a High Lactose Diet and Acth Injections on The White Blood Cell Count, Serum Cortisol and Immunoglobulin G in Young Calves
Effekter av transporter, en diett med høyt laktoseinnhold og ACTH-injeksjoner på antall hvite blodlegemer, serum cortisol og immuno-globulin G hos spedkalver.
Acta Veterinaria Scandinavica volume 21, pages 278–290 (1980)
Abstract
Twelve calves were subjected to 5 different, consecutive treatments considered to induce stress. These included a) transportations for 4–8 h at temperatures just above or well below 0°G at the start of the experiment and 6 and 11 weeks later, b) feeding a high lactose diet and c) ACTH injections.
The transportations resulted in a transient suppression in the level of serum IgG, and increase of Cortisol, blood neutrophils and lymphocytes. One and 2 weeks after the first transportation, the lymphocyte count was suppressed.
Intramuscular injections of ACTH also resulted in temporary increases in serum Cortisol, blood neutrophils and lymphocytes, but no obvious changes in IgG. Thus, the suppressed levels of IgG which were seen after the transportations did not appear to be directly related to the increased level of Cortisol.
The high lactose diet was not accompanied by a significantly higher frequency of diarrhoea and lower mean weight gain. The IgG level did not appear to be influenced by the lactose level of the diet, and calves fed a high lactose diet responded similarly to transportation as calves fed a normal type of milk replacer. Apart from some diarrhoea, no health problem occurred.
Sammendrag
Tolv kalver ble utsatt for 5 forskjellige, påfølgende behandlinger for å påføre dem stress. Disse inkluderte a) transporter med 4–8 timers varighet ved temperaturer litt over eller noe under 0°C ved forsøkets begynnelse, 6 og 11 uker senere, b) melkediett med høyt innhold av laktose og c) ACTH-injeksjoner.
Transportene førte til en forbigående reduksjon i seruminnholdet av IgG, og en forøkelse av cortisol, neutrofile leukocytter og lymfocytter. En og to uker etter den første transporten var innholdet av lymfocytter nedsatt.
Intramuskulære injeksjoner av ACTH førte også til en forbigående forøkelse i seruminnholdet av cortisol samt antall neutrofile leukocytter og lymfocytter, men ingen entydige forandringer i innholdet av IgG. Det nedsatte nivået av IgG som følge af transportene syntes derfor ikke å være direkte relatert til forøkelsen av cortisolnivået som ble observert.
Fóring med en melkediett med høyt laktoseinnhold førte til en høyere frekvens av diarré og lavere gjennomsnittlig vektøkning, men forskjellen til gruppen som ble gitt en mer normal melkeerstatning var ikke signifikant. Det ble ikke funnet noen sammenheng mellom ulik laktosemengde i dietten og serumnivået av IgG, og de målte effekter av transport ble ikke funnet å vaere påvirket av diettene. Bortsett fra diarré ble det ikke registrert helseproblemer.
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Simensen, E., Laksesvela, B., Blom, A.K. et al. Effects of Transportations, a High Lactose Diet and Acth Injections on The White Blood Cell Count, Serum Cortisol and Immunoglobulin G in Young Calves. Acta Vet Scand 21, 278–290 (1980). https://doi.org/10.1186/BF03546890
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DOI: https://doi.org/10.1186/BF03546890