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Plasma and Tissue Levels of Trimethoprim in The Rainbow Trout, Salmo Gairdneri, After Absorption From Fresh and Salt Water
Plasma- og vevskonsentrasjoner av trimethoprim hos regnbueørret, Salmo gairdneri, etter absorpsjon fra ferskvann og saltvann.
Acta Veterinaria Scandinavica volume 21, pages 18–25 (1980)
Abstract
This is a comparative study of uptake of trimethoprim from 1) fresh water, 2) salt water after 7 days of adaption and 3) salt water without previous adaptation. The rate and extent of absorption were found to vary significantly. The salt water adapted group reached a plasma concentration of approx. 1 µg/ml after 10 h, the unadapted salt water group after 24 to 48 h and the fresh water group did not reach this concentration. The results are discussed in relation to the non-ionic diffusion theory and to the alterations taking place in euryhaline species of fish during adaptation to salt water.
Sammendrag
Det er foretatt en undersøkelse over i hvilken grad regnbueørret, Salmo gairdneri, kan absorbere trimethoprim fra ferskvann, fra saltvann etter forutgående adaptasjon og fra saltvann uten adaptasjon. En viss absorpsjon fant sted i alle tre grupper. Fra ferskvann gikk imidlertid absorpsjonen så langsomt at man ikke nådde opp i terapeutiske plasma-konsentrasjoner i løpet av de 84 timer forsøket varte. Ved opptak fra saltvann uten adaptasjon ble det oppnådd terapeutiske konsentrasjoner etter ca. 24 timer, og ved opptak fra saltvann med adaptasjon etter ca. 12 timer. Mulige årsaker til forskjellene mellom de tre grupper blir diskutert.
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Bergsjø, T., Søgnen, E. Plasma and Tissue Levels of Trimethoprim in The Rainbow Trout, Salmo Gairdneri, After Absorption From Fresh and Salt Water. Acta Vet Scand 21, 18–25 (1980). https://doi.org/10.1186/BF03546896
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DOI: https://doi.org/10.1186/BF03546896