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Staphylococcal Nuclease in Udder Secretions of Cows with Acute Mastitis
Stafylokokknuklease i jursekret fra kyr med akutt mastitt.
Acta Veterinaria Scandinavica volume 21, pages 79–95 (1980)
Abstract
High concentrations of nuclease produced by Staphylococcus aureus were demonstrated within a few hours by direct examination of udder secretions from cows with a severe staphylococcal mastitis. A positive correlation between the nuclease concentration and the severity of the mastitis was found. The cows with high nuclease concentrations were generally young individuals and/or in the first 2 weeks of the lactation period. Most had a low titre of antibodies against staphylococcal nuclease. Two-thirds of the cows in which high nuclease concentrations were demonstrated were culled or died because of the mastitis attack.
The role which nuclease plays for staphylococcal virulence is discussed, and it is concluded that nuclease contributes to the pathogenicity of S. aureus.
Sammendrag
Høye konsentrasjoner av nuklease produsert av Staphylococcus aureus kan påvises i løpet av få timer ved en direkte undersøkelse av jursekretet fra kyr med alvorlig stafylokokkmastitt. Det er funnet en positiv korrelasjon mellom nukleasekonsentrasjonen og graden av sykdom. Kyr med store mengder nuklease i sekretet var vanligvis yngre dyr og/eller de befant seg i de to første ukene av laktasjonsperioden. De fleste av dem hadde et lavt titer av antistoffer mot stafylokokknuklease. Omtrent to tredjedeler av kyrne med høye nukleasekonsentrasjoner ble slaktet eller de døde på grunn av mastitt-tilfellet.
Betydningen av enzymet nuklease for virulensen av stafylokokker blir diskutert. En av konklusjonene er at enzymet nuklease bidrar til patogeniteten hos S. aureus.
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Gudding, R. Staphylococcal Nuclease in Udder Secretions of Cows with Acute Mastitis. Acta Vet Scand 21, 79–95 (1980). https://doi.org/10.1186/BF03546903
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DOI: https://doi.org/10.1186/BF03546903