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Treatment of Bovine Ketosis with Invert Sugar, Glucocorticoids, and Propylene Glycol

Behandling av ketos med invert socker, glukokortikoider och propyten glykol

Acta Veterinaria Scandinavica volume 25, pages 467–479 (1984)Cite this article

Abstract

Four different treatments of bovine ketosis, using 3 different pharmaceutical preparations, were monitored. The main antiketogenic and glucogenic ingredients of the preparations were as follows: invert sugar (Metabol), prednisolone and dexamethasone (Predasen), the former preparations combined (Metabol & Predasen) and propylene glycol and dexamethasone (Dexaprol). Blood samples were drained from the ketotic cows prior to the treatment. The animals were sampled again 2 and 7 days after the first sampling. The whole blood concentrations of acetoacetate (AA concn), β-hydroxybutyrate (BHB concn) and glucose (glue concn) were determined. The measures of the antiketogenic and glucogenic efficacy of the various treatments applied were their ability to reduce the AA concn and BHB concn and to elevate the gluc concn.

Invert sugar (Metabol) alone had no antiketogenic efficacy, although in some cases it led to a subjective clinical improvement as reported by the owners of the animals. Invert sugar and glucocorticoids (Metabol & Predasen) dexamethasone and prednisolone (Predasen) and dexamethason plus propylene glycol (Dexaprol) were equally effective in bringing the AA, BHB and glue concns to normal range. The mean glue concn of the cows treated with Dexaprol was higher than that of the cows in the other treatment groups at 2 days (P < 0.01). No other differences between the 3 antiketogenic treatments could be shown.

Sammanfattning

Fyra olika behandlingsmetoder av ketos undersöktes. Tre farmaceutiska preparat användes i behandlingen. Preparatens huvudsaklika antiketogena och glukogena beståndsdelar var följande: invert-socker (Metabol), Prednisolon och dexametason (Predasen), de föregående preparaten tillsammans (Metabol och Predasen) och propylen glykol och dexametason (Dexaprol). Före behandlingen togs blodprov från korna. På den andra och sjunde dagen efter den första provtagningen omtogs blodprov från djuren. Koncentrationen i blodet av acetoacetat (AA), β-hydroxybutyrat (BHB) och glukos (gluc) bestämdes. Förmägan att sänka koncentrationen av AA och BHB i blodet och att höja gluc koncentrationen användes som mått på antiketogen och glukogen effekt hos de olika behandlingsmetoderna.

Invertsocker (Metabol) aliena hade ingen antiketogen effekt, ehuru det gav en subjektiv klinisk förbättring enligt djurens ägare i några fall. Invertsocker och glukokortikoider (Metabol och Predasen), dexametason och Prednisolon (Predasen) och dexametason plus propylen glykol (Dexaprol) var lika effektiva när det gällde att få blodkoncentrationen av AA, BHB, och gluc tili normal nivå. Dexaprol ökade blodkoncentrationen av gluc mera än de andra behandlingsmetoderna (P < 0.01) 2 dagar efter behandlingen. Ingen annan skillnad mellan de 3 antiketogena behandlingarna kunde påvisas.

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Authors and Affiliations

  1. Department of Biochemistry, College of Veterinary Medicine, Helsinki, Finland

    Kauko Kauppinen & Yrjö Gröhn

  2. Department of Animal Hygiene and Clinical Nutrition, College of Veterinary Medicine, University of Agricultural Sciences, Uppsala, Sweden

    Kauko Kauppinen & Yrjö Gröhn

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  1. Kauko Kauppinen
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  2. Yrjö Gröhn
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Kauppinen, K., Gröhn, Y. Treatment of Bovine Ketosis with Invert Sugar, Glucocorticoids, and Propylene Glycol. Acta Vet Scand 25, 467–479 (1984). https://doi.org/10.1186/BF03546915

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Acta Veterinaria Scandinavica

ISSN: 1751-0147