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Platelet Aggregation in Dogs After Live-Virus Vaccination
Trombocytaggregation hos hundar efter vaccinering med levande virusvaccin.
Acta Veterinaria Scandinavica volume 25, pages 504–509 (1984)
Abstract
Platelet aggregation induced by ADP was studied in dogs after vaccination with a modified live-virus distemper vaccine. A significant decrease in platelet counts was observed about 1 week after the vaccination. There were no consistent changes in the aggregability of the platelets. In 4 samples the aggregability was significantly increased compared to the prevaccination values. The observed changes will not cause a defective hemostasis in otherwise normal dogs.
Sammanfattning
ADP-inducerad trombocytaggregation mättes hos hundar efter vaccinering med ett modifierat levande valpsjukevaccin. En signifikant sänkning av antalet trombocyter sågs ungefär en vecka efter vaccineringen. Inga systematiska förändringar sågs av trombocyteraas aggregationsförmåga. I fyra fall sågs en signifikant ökning av aggregationsförmågan jämfört med utgångsvärden före vaccinering. De observe-rade förändringarna efter vaccination kommer inte att ge sämre hemostas hos tidigare friska hundar.
References
Chernesky, M. A., R. P. B. Larke & A. G. G. Turpie: Interaction between viruses and platelets: Requirement of haemolytic activity for platelet aggregation induced by paramyxoviruses. J. gen. Virol. 1973, 21, 205–213.
Johnstone, I. B.: Comparative effects of phenylbutazone, Naproxen and Flunixin Meglumine on equine platelet aggregation and platelet factor 3 availability in vitro. Canad. J. comp. Med. 1983, 47, 172–179.
Jones, B.-E. V.: Platelet aggregation in dogs with decreased platelet counts caused by vaccination with a modified live-virus vaccine. Proc. 14th Nordic Vet. Congr., Copenhagen, Denmark, 6–9 July 1982, p. 422.
Pineau, S., L. W. Belbeck & S. Moore: Levamisole reduces the thrombocytopenia associated with myxovirus vaccination. Canad. vet. J. 1980, 21, 82–84.
Scott, S., H.-J. Reimers, M. A. Chernesky, J. P. Greenberg, R. L. Kinlough-Rathbone, M. A. Packham & J. F. Mustard: Effect of viruses on platelet aggregation and platelet survival in rabbits. Blood 1978, 52, 47–55.
Straw, B.: Decrease in platelet count after vaccination with distemperhepatitis (DH) vaccine. Vet. Med. Small Anim. Clin. 1978, 6, 725–726.
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Jones, B.E.V. Platelet Aggregation in Dogs After Live-Virus Vaccination. Acta Vet Scand 25, 504–509 (1984). https://doi.org/10.1186/BF03546918
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DOI: https://doi.org/10.1186/BF03546918