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Oral 1,25-Dihydroxyvitamin D3 in Prevention of Milk Fever
Melkefeberprofylakse ved oral tilførsel av 1,25-dihydroxyvitamin D3.
Acta Veterinaria Scandinavica volume 25, pages 510–525 (1984)
Abstract
The effect of daily oral doses of 1,25-dihydroxy vitamin D3 (1,25-(OH)2D3) on plasma mineral concentrations and incidence of milk fever was tested in 39 aged cows. Three dose levels of 1,25-(OH)2D3 (0, 100 and 200 µg/d) were compared in cows supplemented with 100 g Ca/d (250 g CaCO3) and in cows receiving no Ca supplement. 1,25-(OH)2D3 treatments were given from day 5 before expected calving (day –5) until the day after calving (Calving = day 0).
Expected minima in Ca concentrations in plasma were seen on day 1 in placebo treated cows, while Ca concentrations in 1,25-(OH)2D3 treated cows were normal or increased in the period from start of treatment until day 3–5. In the parturient period (day –1 to +2) 1 of 21 treated cows developed milk fever, as compared to 4 of 18 untreated. A pronounced hypocalcaemia developed, however, in the 1,25-(OH)2D3 treated cows from day 3 to 5 onwards, culminating day 8–11 with 7 cases of milk fever. Ca supplements reduced the development of hypocalcaemia in the 1,25-(OH)2D3 treated cows, but could not completely prevent the occurrence of milk fever.
Sammendrag
Virkningene av daglige orale doser av 1,25-dihydroksyvitamin D3 (1,25-(OH)2D3) på innhold av mineraler i plasma og på forekomst av melkefeber ble studert hos 39 eldre kyr. Tre dose-nivåer av 1,25-(OH)2D3 (0, 100 og 200 µg/d) ble sammenlignet hos dyr med og uten tilskudd av 100 g Ga/d (250 g CaCO3). Behandling ble gitt fra dag 5 før forventet kalving (dag –5) til dagen etter kalving (Kalving = dag 0).
Gjennomsnittlig plasma Ga nivå var normalt eller forhøyet under behandlingen og gjennom kalvingsperioden fram til dag 3–5. I kalvingsperioden fikk 1 av 21 behandle de og 4 av 18 ubehandlede dyr melkefeber. Mens ubehandlede raskt normaliserte plasma Ga etter kalving utviklet samtlige behandlede dyr hypokalsemi og hypofosfatemi som kulminerte dag 8–11 med 7 tilfeller av melkefeber. Tilførsel av ekstra GaCO3 reduserte, men kunne ikke forhindre utvikling av hypokalsemi.
References
Bjorklund, N. E., G. Jonsson & B. Pehrson: Effects and side effects of parenterally administered 1-α-hydroxy cholecalciferol (1α-OHD3) to cows. Reports & Abstracts. 9th Int. Congr. on Diseases in Cattle, Paris. 1976, 1003–1006.
Contreras, P. A., R. Manston & B. F. Sansom: Calcium mobilization in hypomagnesaemic cattle. Res. Vet. Sci 1982, 33, 10–16.
Ekern, A. & L. Vik-Mo: Standard and lead feeding of dairy cows. Livest. Prod. Sci. 1983, 10, 443–455.
Gast, D. R., R. L. Horst, N. A. Jorgensen & H. F. DeLuca: Potential use of 1,25-dihydroxycholecalciferol for prevention of parturient paresis. J. Dairy Sci. 1979, 62, 1009–1013.
Green, H. B., R.L. Horst, D. C. Beitz & E. T. Littledike: Vitamin D metabolites in plasma of cows fed a prepartum low-calcium diet for prevention of parturient hypocalcemia. J. Dairy Sci. 1981, 64, 217–226,
Halse, K.: Calcium effects on renal conservation of magnesium in cows. Acta vet. scand. 1984, 25, 213–228.
horst, R. L., J. A. Eisman, N. A. Jorgensen & H. F. DeLuca: Adequate response of plasma 1,25-dihydroxyvitamin D to parturition in paretic (milk fever) dairy cows. Science 1977, 196, 662–663.
Hove, K.: Intestinal radiocalcium absorption in the goat: measurement by a double isotope technique. Brit. J. Nutr. 1984, 51, 145–156.
Hove, K.: Effects of 1α-hydroxylated metabolites of cholecalciferol on intestinal radiocalcium absorption in goats. Brit. J. Nutr. 1984, 51, 157–164.
Hove, K. & T. Kristiansen: Prevention of parturient hypocalcemia: Effect of a single oral dose of 1,25-dihydroxy vitamin D3. J. Dairy Sci. 1982, 65, 1934–1940.
Hove, K., R. L. Horst & E. T. Littledike: Effects of 1α-hydroxvitamin D3, 1,25-dihydroxyvitamin D3, 1,24,25-trihydroxyvitamin D3, and l,25,26-trihydroxyvitamin D3 on mineral metabolism and 1,25-dihydroxyvitamin D concentrations in dairy cows. J. Dairy Sci. 1983, 66, 59–66.
Mazor, Z., B. Machnai, J. Sterling, B. Z. Weiner, A. Rubinstein, N. Kain, I. Friedman, M. Sieffe, A. DeVries, E. Meir & M. Sachs: The prevention of milk fever with 1α-hydroxyvitamin D3 (1α(OH)D3) administered in a precise regimen. Proc. XI Int. Congr. Diseases in Cattle, Tel Aviv, 1980, 1262.
McMurray, C. H., D. A. Rice & P. S. McBride: Milk fever controls: Comparison of 1-alpha and vitamin D3 in conjunction with induced parturition. Vet. Rec. 1980, 107, 188–191.
McMurray, C. H., D. A. Rice, F. Gordon & D. Humpheries: The potential use of Solanum malacoxylon in the prevention of parturient paresis in dairy cows. Proc. 5. Int. Conf. Production Diseases in Farm Animals, Uppsala 1983, p. 22–25.
Mullen, P. A., P. G. C. Bedford & P. L. Ingram: An investigation of the toxicity of la-hydroxycholecalciferol to calves. Res. Vet. Sci. 1979, 27, 275–279.
Sachs, M., B. Machnai, D. Ochovsky, Y. Miller, D. Sabag, Y. Danieli, E. Meir, A. Bar, S. Hurwitz, J. Sterling, B. Weiner, N. Kain, M. Seife & Z. Mazor: The use of 1α-hydroxycholecalciferol in the prevention of bovine parturient paresis (milk fever). Proc. Fifth Intern. Conf. Prod. Diseases in Farm Animals 1983, 14–18.
Sansom, B. F., W. M. Allen, D. C. Davies, M. N. Hoare, J. R. Stenton & M. J. Vagg: Use of 1α-OH cholecalciferol in preventing post parturient hypocalcaemia and its potential value for the prevention of milk fever in dairy cows. Vet. Rec. 1976, 99, 310–312.
Wittwer, F. G. & E. J. H. Ford: 1α-hydroxycholecalciferol in the prevention of milk fever. Vet. Rec. 1978, 102, 442–443.
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Hove, K., Kristiansen, T. Oral 1,25-Dihydroxyvitamin D3 in Prevention of Milk Fever. Acta Vet Scand 25, 510–525 (1984). https://doi.org/10.1186/BF03546919
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DOI: https://doi.org/10.1186/BF03546919