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Impairment of Neutrophil Functions in a Dog with an Eosinophilic Dermatosis

Hœmmet granulocytfunktion hos en hund med en eosinofil dermatose

Acta Veterinaria Scandinavica volume 32, pages 519–526 (1991)Cite this article

Abstract

An eosinophilic dermatosis was diagnosed in a dog with a multifocal distribution of pruritic, pustular and erosive lesions on the trunk. Ectoparasites, fungi and bacteria were not detected in the skin of the dog. At a subsequent admission to the university clinic, bacterial conjunctivitis and superficial pyoderma had developed. At a time when the dog received no medical therapy, evaluation of phagocytosis and chemotactic migration towards a variety of chemotactic factors revealed a general suppression of patient neutrophil responsiveness, as compared to a control dog. Viability of the patient’s neutrophils was normal. It was proposed that deactivation of neutrophil functions occurred following exposure to suppressive factors from mast cells, or as a consequence of surface receptor down-regulation due to prolonged cell activation by as yet unknown stimulants. The observed susceptibility to infections in the dog suffering from a primary, sterile eosinophilic dermatosis may be related to impaired host defence against opportunistic microorganisms.

Sammendrag

En eosinofil dermatose blev diagnosticeret hos en hund med multifokale, kløende, pustulære og erosive læsioner på truncus. Der kunne ikke påvises ektoprasitter, svampe eller bakterier på/i patientens hud. Ved en senere hospitalsindlæggelse diagnosticeredes bakteriel konjunktivitis og superficiel pyodermi. På et tidspunkt, hvor hunden ikke var under medicinsk behandling påvistes, i forhold til en kontrolhund, et generelt nedsat fagocytrespons, bedømt ved måling af granulocyt-kemo-taxi og fagocytose. Deaktivering af nævnte cellefunktioner foreslåes sat i forbindelse, enten med mastcelle-frigørelse af suppressive faktorer, eller med receptornedregulering som følge af prolongeret celleaktivering med ukendte, inflammations-associerede stimuli. Konklusivt kan den observerede prædisponering for infektion hos en hund med en primaer, steril eosinofil dermatose muligvis saettes i relation til et nedsat forsvarsberedskab overfor opportunistiske patogener.

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Authors and Affiliations

  1. Department of Pharmacology, Leo Pharmaceutical Products, Ballerup, Department of Clinical Studies, and Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Novo Nordisk A/S, Niels Steensensvej 8, DK-2820, Frederiksberg, Gentofte, Denmark

    M. Krogsgaard Thomsen, A. Lundorff Jensen, E. Bindseil & F. Kristensen

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  1. M. Krogsgaard Thomsen
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  2. A. Lundorff Jensen
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  3. E. Bindseil
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  4. F. Kristensen
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Krogsgaard Thomsen, M., Lundorff Jensen, A., Bindseil, E. et al. Impairment of Neutrophil Functions in a Dog with an Eosinophilic Dermatosis. Acta Vet Scand 32, 519–526 (1991). https://doi.org/10.1186/BF03546953

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Acta Veterinaria Scandinavica

ISSN: 1751-0147