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Effect of a Prostaglandin F2α Analogue Prostinfenem (15-Methyl-PGF2α), to Induce Luteolysis and Oestrus in Heifers

Effekt av en prostaglandin F2α analog, Prostinfenem (15-Methyl-PGF2α), för att inducera luteolys och brunst hos kvigor.

Acta Veterinaria Scandinavica volume 32, pages 327–335 (1991)Cite this article

Abstract

Different doses of 15-methyl-PGF2α (0.125–10 mg) were used to induce luteolysis and oestrus in 7 heifers with 28 treatments on day 8–12 of the oestrous cycle. Twenty-three out of 28 treatments gave the desired response and the animals showed signs of oestrus within 5 days post-injection. The doses of 0.25–10 mg can be used to induce luteolysis and oestrus. The dose of 0.125 mg was not effective to induce luteolysis and only 1 out of 4 treatments responded. When higher doses were given (1–10 mg), progesterone levels decreased more rapidly and reached 1 nmol/l 16.2 h earlier than in animals which responded to doses < 1 mg. The minimum effective dose was considered to be 0.25 mg. Clinical signs of oestrus, regression of corpus luteum and variation in the interval to oestrus were similar as for PGF2α or its other analogues. By measurement of the main circulating prostaglandin F2α metabolite, it was found that an endogenous PGF2α release occurred 1–3 days post-injection of 15-methyl-PGF2α. Furthermore in cases of post-oestrous bleedings an endogenous PGF2α release was also seen concomitantly with the bleeding. This prostaglandin analogue seems to be useful for farm management and can be an alternative to other PGF2α analogues.

Sammanfattning

Tjugoåtta injektioner av 15-metyl-PGF2α i doserna 0,125–10 mg gavs för att inducera luteolys och brunst på 7 kvigor på dag 8–12 av brunstcykeln. 123 av 28 fall gav behandlingen önskat resultat och djuren visade brunst inom 5 dagar efter injektionen. Doser mellan 0,25 mg och 10 mg kan användas för att inducera luteolys och brunst. Dosen 0,125 mg inducerade luteolys endast i 1 fall av 4. När högre doser gavs (1–10 mg) minskade progesteronnivåerna snabbare och nivån < 1 nmol/l nåddes 16,2 timmar tidigare än hos djur som svarade på doser under 1 mg. Minsta effektiva dos var 0,25 mg. Kliniska brunstsymptom, gulkroppens regression och variationen i tiden till brunst efter injektion liknade svaret efter injektion av PGF2α och andra prostaglandinanaloger. Genom att mäta prostaglandin F2α′s huvudmetabolit, påträffades en endogen frisättning av PGF2α 1-3 dagar efter injektionen. I de fall där blodflytning forekom efter brunsten kunde också en endogen frisättning uppmätas. Sammanfattningsvis kan sägas att denna nya prostaglandinanalog är ett fullgott alternativ till tidigare använda prostaglandinanaloger.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, P. O. Box 7039, S-750 07, Uppsala, Sweden

    S. Aiumlamai

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Aiumlamai, S. Effect of a Prostaglandin F2α Analogue Prostinfenem (15-Methyl-PGF2α), to Induce Luteolysis and Oestrus in Heifers. Acta Vet Scand 32, 327–335 (1991). https://doi.org/10.1186/BF03546962

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Acta Veterinaria Scandinavica

ISSN: 1751-0147