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A Case of Trisomy 22 in a Live Hereford Calf

Et tilfælde af den sjældne kromosomdefekt trisomi 22 hos en levende kalv er beskrevet. Kalven havde lavt blod-thyroxine-niveau og lav vækstrate

Acta Veterinaria Scandinavica volume 40, pages 85–88 (1999)Cite this article

Abstract

A case of the rare genetic trisomy 22 in a live calf is described. The calf had low blood thyroxine level and low growth rate. It had several defects including brachygnathia superior, strabismus convergence, aortal cusp insufficiency and hypertrophy of clitoris. Chromosome analysis was performed on cultured blood lymphocytes and fibroblast cells. In all counted metaphases 61 chromosomes were present. The extra chromosome was identified as a chromosome 22 by R-banding. The defects of the calf have similarities with cases of partial trisomy 3p25-pter in human. This section of the human chromosome 3 corresponds to sections of cattle chromosome 22.

Sammendrag

Den havde adskillige defekter såsom brachygnathia superior, strabismus convergens, aortal cusp insufficiens og hypertrofi af clitoris. Kromosomanalyse blev gennemført på lymfocyt og fibroblast cellekulturer. I alle talte metafaser var der 61 kromosomer. Det ekstra kromosom blev identificeret som kromosom 22 ved R-bånds farvemetoden. Kalvens defekter har ligheder med defekter hos tilfælde af partiel trisomi 3p25-pter hos mennesker. Denne sektion af det humane kromosom 3 svarer til sektioner af kvægets kromosom 22.

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Authors and Affiliations

  1. Division of Animal Genetics, Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Grønnegårdsvej 3, DK-1870, Frederiksberg C, Denmark

    K. Christensen

  2. Department of Clinical Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark

    L. Juul

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  1. K. Christensen
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  2. L. Juul
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Correspondence to K. Christensen.

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Christensen, K., Juul, L. A Case of Trisomy 22 in a Live Hereford Calf. Acta Vet Scand 40, 85–88 (1999). https://doi.org/10.1186/BF03547044

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Acta Veterinaria Scandinavica

ISSN: 1751-0147