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Therapeutic Trials in Dogs with Experimental Hepatitis Contagiosa Canis

Behandlungsversuche an Hunden mit experimenteller H.c.c

Terapiförsök på hundar med experimentell Hepatitis contagiosa canis

Summary

The effect of some substances on the temperature, total leucocyte count, and plasma levels of glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, and ornithine carbamyl transferase has been studied in dogs with experimentally produced Hepatitis contagiosa canis. Neither the hyperimmune serum Serasix (Pitman-Moore), nor 1 % prednisolone (AGO), nor 6 % Macrodex® (Pharmacia), nor 10 % Rheomacrodex® (Pharmacia) had any beneficial effect on the course of the disease. Opacity of the cornea arose in all the surviving prednisolone-treated dogs. In a group of normal dogs, treatment with Macrodex and Rheomacrodex led to a rise of the glutamic-oxaloacetic transaminase levels within 24 hours but caused no rise of the ornithine carbamyl transferase levels.

Zusammenfassung

Mittels der Registrierung der Temperatur, Gesamtanzahl der Leukocyten, der Plasmaaktivität von GOT, GPT und OCT, wurde die Wirkung gewisser Medikamente auf die experimentelle H.c.c. untersucht. Die angewendeten Mittel wie das hyperimmune Serum Serasix (Pitman-Moore), 1 % Prednisolon (AGO), 6 % Macrodex® (Pharmacia) oder 10 % Rheomacrodex® (Pharmacia), hatten keinen Einfluss auf den Krankheitsverlauf ausgeübt. Bei allen mit Prednisolon behandelten Hunden die überlebten, wurde eine Trübung der Hornhaut beobachtet. Die Behandlung der gesunden Hunde mit Macrodex und Rheomacrodex, ergab binnen 24 Stunden eine Erhöhung der Plasma-GOT-Werte, hatte jedoch keinen Einfluss auf die OCT-Werte.

Sammanfattning

Genom att följa temperatur, totalantalet leukocyter, plasmaaktiviteterna av GOT, GPT och OCT har effekten av några medel pro vats vid experimentell H.c.c. Inget av de använda medlen hyperimmuneserum Serasix (Pitman-Moore), 1 % Prednisolon (ACO), 6 % Macro-dex® (Pharmacia) eller 10% Rheomacrodex(g) (Pharmacia) påverkade sjukdomsutvecklingen i positiv riktning. Samtliga överlevande prednisolonbehandlade hundar erhöllo corneagrumling. Macrodex- och Rheomacrodexbehandlingar av friska hundar gav inom 24 timmar en höjning av plasma GOT-värdena, men påverkade inte OCT värdena.

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Correspondence to Gert Lindblad.

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Supported by grants from “Anslag för främjande av medicinsk forskning vid Veterinärhögskolan”.

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Lindblad, G. Therapeutic Trials in Dogs with Experimental Hepatitis Contagiosa Canis. Acta Vet Scand 6, 1–15 (1965). https://doi.org/10.1186/BF03547062

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