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Urinary Excretion of Oestrone and Oestradiol and of Zimmermann Chromogens in the Sow During Oestrus

Die Ausscheidung von Östrogenen und Zimmermann-Chromogenen mit dem Harn von Säuen während des Östrus

Utskillelsen av østrogener og Zimmermann-kromogener med urinen hos purke under østrus

Summary

By analyses of 24 hrs. urine, the excretion of oestrone and oestradiol and of Zimmermann chromogens, comprizing 17-ketosteroids, was estimated in sows during oestrus. Generally it was found that the excretion of oestrogens increased during vaginal oestrus. The maximal excretion of oestrogens, mean: 95 µg per 24 hrs. (n = 5), occurred at the first day of psychic oestrus. On the following day the mean value was 14 µg per 24 hrs. The decrease in the rate of excretion of oestrogens during the course of psychic oestrus was more pronaunced than the corresponding decrease in the urinary concentration of oestrogens, means: 20 µg to 7 µg per 1, due to appreciable variations in the volume of the 24 hrs. urine during oestrus. The relationships in time between the oestrogen excretion and the vaginal and the psychic oestrus is discussed.

The amounts of oestradiol in the urine were relatively small, rarely constituting more than 1/10 of the sum total oestrone and oestradiol. The excretion of oestradiol was demonstrated to increase appreciably during oestrus except in one animal which, despite development of hyperemia and edema of the vulva, failed to come into psychic oestrus.

Large variations were found in the excretion of Zimmermann chromogens (expressed as equivalents of dehydroepiandrosterone: 1 to 9 mg per 24 hrs.) but these appeared to occur independently of the variations in the excretion of oestrogens.

Zusammenfassung

Bei Analysen von Harn ausgeschieden im Laufe von 24 Stunden, wurde die Ausscheidung von Östron und östradiol und von Zimmermann-Chromogenen, welche die 17-Ketosteroiden umfassen, bei Säuen während des Östrus bestimmt. Im allgemeinen zeigte es sich, dass die Ausscheidung von Östrogenen während des vaginalen Östrus zustieg. Die maximale östrogenausscheidung, Mittel: 95 jug pro 24 Stunden (n = 5), zeigte sich am ersten Tag des psychischen Östrus. Am folgenden Tag war der Mittelwert 14 µg pro 24 Stunden. Der Fall in der Totalausscheidung der Östrogene im Laufe des psychischen Östrus war grösser als der entsprechende Fall in der östrogenkonzentration des Harns, Mittel: 20 µg bis 7 µg pro Liter, da das tägliche Harnvolumen während des Östrus grossen Variationen ausgesetzt war. Die Zeitverhältnisse in Bezug auf die östrogenausscheidung und auf den vaginalen und psychischen Östrus werden diskutiert.

Die östradiolmengen im Harn waren verhältnismässig gering und machten selten mehr als 1/10 der Summe von Östron und östradiol aus. Ein bedeutender Anstieg in der östradiolausscheidung während des Östrus wurde bei allen Tieren festgestellt — mit einer Ausnahme, wo trotz Hyperämie und ödem in der Vulva kein psychischer Östrus eintraf.

Grosse Variationen in der Ausscheidung von den Zimmermann-Chromogenen wurden festgestellt (ausgedrückt als Äquiavalenten von Dehydroepiandrosteron: 1 bis 9 mg pro 24 Stunden). Jedoch schienen diese unabhängig von den Variationen in der östrogenausscheidung stattzufinden.

Sammendrag

Ved analyser av døgnurin ble utskillelsen av østron og østradiol og av Zimmermann kromogener, omfattende 17-ketosteroider, bestemt hos purker under østrus. Stort sett ble det funnet at utskillelsen av østrogener steg under vaginal østrus. Den maksimale østrogenutskillelse, middel: 95 µg per 24 t (n = 5), fant sted ved første dag av psykisk østrus. Den påfølgende dag var middelverdien 14 µg per 24 t. Fallet i totalutskillelsen av østrogener i løpet af psykisk østrus var mer uttalt enn det tilsvarende fall i urinens konsentrasjon av østrogener, middel: 20 µg til 7 µg per 1, i det urinens døgnvolum undergikk betydelige variasjoner under østrus. Forholdene i tid med hensyn på østrogenutskillelsen og på den vaginale og den psykiske østrus diskuteres.

Mengdene av østradiol i urinen var forholdsvis små og utgjorde sjelden mer enn 1/10 av summen østron og østradiol. Det ble påvist en betydelig økning av østradiolutskillelsen under østrus unntatt hos ett dyr som, til tross for utvikling av hyperemi og ødem i vulva, ikke kom i psykisk østrus.

Det ble funnet store variasjoner i utskillelsen av Zimmermannkromogener (uttrykt som ekvivalenter av dehydroepiondrosteron: 1 til 9 mg per 24 t), men disse syntes å finne sted uavhengig av variasjonene i østrogenutskillelsen.

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Correspondence to Torleiv Lunaas.

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Lunaas, T. Urinary Excretion of Oestrone and Oestradiol and of Zimmermann Chromogens in the Sow During Oestrus. Acta Vet Scand 6, 16–29 (1965). https://doi.org/10.1186/BF03547063

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