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Studies on in Vitro Erythrocyte Uptake of I131-Labelled 1-Triiodothyronine as A Test of Thyroid Function in Dairy Cattle

Untersuchungen über die Aufnahme von J-131-gemerkten l-Trijodthyronins in Erythrocyten in vitro als Test der Thyreoideafunktion bei Rindern

Undersökningar över erythrocyter nas upptag in vitro av J131-märkt Trijodthyronin som en test på thyreoideafunktionen hos nötkreatur

Summary

Uptake of I131-labelled triiodothyronine by erythrocytes (EU test) as a test of thyroid function has been studied in cattle. The normal EU value for 141 Swedish Red-and-white cows was 6.99 ± 0.95 (range 4.45–10.23) at an incubation time of one hour. Statistically significantly higher values were obtained for newly-calved cows. The EU values for calves are significantly higher but by 12 to 18 months of age decline to the same level as for older cows.

The principle of the test is described and the results obtained compared with those for human beings. The EU test is suitable for screening thyroid function for large groups of animals and for studying associations between thyroid activity and different production qualities.

Zusammenfassung

Eine Untersuchung über die Aufnahme gemerkten Trijodthyronins (genannt EU-Test, Erythrocyte Uptake) als Test der Thyreoideafunktion bei Rindern wurde vorgenommen. Basiert auf eine Untersuchung von 141 SRB-Kühen erhielt man einen EU-Normalwert von 6,99 ± 0,95 (Grenzwerte 4,45–10,23), wobei doch die Zeit nahe der Kalbung ausgeschlossen wurde, nachdem man statistisch signifikant höhere EU-Werte bei neugekalbten Kühen erhielt. Jungtiere zeigen höhere EU-Werte, die doch mit steigendem Alter sinken, um nach 12–18 Monaten die gleichen, wie die bei älteren Tieren zu sein.

Das Prinzip, worauf der Test baut, wird mit Leitung der Literaturangaben diskutiert. Die erhaltenen Resultate werden mit denen, besonders beim Menschen erhaltenen, verglichen. Die Verfasser schliessen daraus, dass der EU-Test für eine grobe Aussiebung des Thyreoideastatus bei grösserem Tiermaterial, sowie für Untersuchungen des Zusammenhanges zwischen Thyreoideastatus und verschiedenen Produktionseigenschaften sehr anwendbar ist.

Sammanfattning

En undersökning har företagits över erythrocyternas upptag av markt trijodthy ronin (EU-testen) såsom en test på thyreoideafunktionen hos nötkreatur. Baserat på en undersökning av 141 SRB-kor erhölls ett normalvarde på EU av 6,99 ± 0,95 (gränsvärden: 4,45–10,23) varvid dock tiden närmast efter kalvningen uteslutits, eftersom statistiskt signifikant högre EU-värden erhålles hos nykalvade kor. Ungdjur visar högre EU-värden„ vilka sjunker med stigande ålder för att vid 12–18 månaders ålder vara desamma som hos äldre kor.

Den princip varpå testen bygger diskuteras med ledning av litteraturuppgifter. De erhållna resultaten jämföres med motsvarande resultat hos specieilt människa. EU-testen är väl lämpad för screening av thyreoideastatus på ett större djurmaterial liksom vid undersökning av sambandet mellan thyreoideastatus och olika produktionsegenskaper.

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The investigation was aided by grants from The Swedish Agricultural Research Council and The Atomic Energy Research Council.

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Ekman, L., Thorell, C. Studies on in Vitro Erythrocyte Uptake of I131-Labelled 1-Triiodothyronine as A Test of Thyroid Function in Dairy Cattle. Acta Vet Scand 6, 30–40 (1965). https://doi.org/10.1186/BF03547064

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