Skip to main content

Fluorometric Selenium Determinations in the Liver of Normal Pigs and in Pigs Affected with Nutritional Muscular Dystrophy and Liver Dystrophy

Fluorometrische Selenbestimmungen in der Leber normaler Schweinen und Schweinen von ernährungsbedingter Muskeldystrophie angegriffen

Fluorometriska selenbestämningar i leuern hos normala svin och hos svin angripna av nutritionell muskeldystrofi och leverdystrofi

Summary

The selenium concentration of livers and kidneys in normal pigs and in pigs affected with nutritional muscular dystrophy (NMD) and liver dystrophy (LD) was determined. The kidney values showed great variation in normal pigs. The young pigs generally had the lowest levels. The liver values were less scattered.

In NMD and LD the liver contained about 0.2 ppm of selenium on the average, whereas normal livers contained about 1.2 ppm. Kidneys showed corresponding differences. This is in good agreement with the favourable results obtained with selenium therapy.

Zusammenfassung

Die Konzentration von Selen in der Leber und in den Nieren bei normalen Schweinen und bei Schweinen die von ernährungsbedingter Muskeldystrophie (NMD) und Leberdystrophie (LD) angegriffen waren, wurde bestimmt. Das Gehalt der Nieren zeigte grosse Variation bei normalen Schweinen. Die jungen Schweinen hatten das niedrigste Gehalt. Das Gehalt der Leber zeigte kleinere Variation. Bei NMD und LD war das Gehalt von Selen der Leber ungefähr 0,2 ppm, das der normalen Leber ungefähr 1,2 ppm., In den Nieren fand man eine ähnliche Differenz. Diese Observationen sind in guter Übereinstimmung mit den guten Resultaten der Selenbehandlung gegen die beiden Krankheiten.

Sammanfattning

Selenhalten i lever och njurar hos normala grisar samt hos grisar med nutritionell muskeldystrofi (NMD) och leverdystrofi (LD) bestämdes. Njurvärdena visar ganska stor variation hos normala grisar. De minsta grisarna har de lägsta värdena. I levern finns inte någon motsvarande variation. Vid NMD och LD visar levern ungefär 0.2 ppm i medeltal medan normala levrar innehåller ungefär 1.2 ppm. I njurarna fanns motsvarande differenser. Observationerna står i god överensstämmelse med de gynnsamma resultaten av selenbehandlingen vid de nämnda sjukdomarna.

References

  1. 1.

    Bethge, P. O.: Determination of sulfur by wet combustion with perchloric acid. Anal. Chem. 1956, 28, 119.

  2. 2.

    Bode, H.: Systematische Untersuchungen über die Anwendbarkeit Diäthyldithiocarbaminate in der Analyse. Z. Anal. Chem. 1954, 143, 182.

  3. 3.

    Cousins, F. R. & Cairney, M.: Some aspects of selenium metabolisms in sheep. Aust. J. agric. Res. 1961, 12, 927.

  4. 4.

    Ekman, L., Orstadius, K. & Åberg, Br. Distribution of Se75-tagged sodium selenite in pigs with muscular dystrophy. Acta vet. scand. 1963, 4, 92.

  5. 5.

    Grant, C. A. & Tafvelin, B.: Selen och hepatosis diaetetica hos svin. Nord. Vet.-Med. 1958, 10, 657.

  6. 6.

    Grant, C. A., Tafvelin, B. & Christen, R.: Retention of selenium by pig tissues. Acta pharmacol. et toxicol. 1961, 18, 285.

  7. 7.

    Lindberg, P. & Sirén, M.: Selenium concentration in kidneys of normal pigs and pigs affected with nutritional muscular dystrophy and liver dystrophy (hepatosis diaetetica). Life Sciences 1963, no. 5, 326.

  8. 8.

    Obel, A-L.: Studies on the morphology and etiology of so-called toxic liver dystrophy (hepatosis diaetetica) in swine. Thesis Stockholm, 1953.

  9. 9.

    Orstadius, K.„ Nordström, G. & Lannek, N.: Combined therapy with vitamin E and selenite in experimental nutritional muscular dystrophy of pigs. Cornell Vet. 1963, 53, 60.

  10. 10.

    Orstadius, K., Wretlind, B., Lindberg, P., Nordström, G. & Lannek, N.: Plasma- transaminase and transferase activities in pigs affected with muscular and liver dystrophy. Zbl. Vet. Med. 1959, 6, 971.

  11. 11.

    Orstadius, K. & Åberg, B.: Distribution of Se75-tagged sodium selenite in pigs. Acta vet. scand. 1961, 2, 60.

  12. 12.

    Parker, C. A. & Harvey, L. G.: Luminescence of piazselenols. A new fluorimetric reagent for selenium. Analyst 1962, 87, 658.

  13. 13.

    Schwarz, K.: Factor 3, selenium and Vitamin E. Nutr. Rzv. 1960–61, 18, 193.

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Paul Lindberg.

Additional information

Supported by grants from Jordbrukets Forskningsråd and Medicinska Forskningsrådet.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lindberg, P., Siren, M. Fluorometric Selenium Determinations in the Liver of Normal Pigs and in Pigs Affected with Nutritional Muscular Dystrophy and Liver Dystrophy. Acta Vet Scand 6, 59–64 (1965). https://doi.org/10.1186/BF03547067

Download citation