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Retention of Selenium in Kidneys, Liver and Striated Muscle After Prolonged Feeding of Therapeutic Amounts of Sodium Selenite to Pigs

Über die Zurückhaltung von Selen in Niere, Leber und querstreifiger Muskulatur des Schweines nach langzeitiger Verabreichung therapeutischer Gaben von Natriumselenit

Retention av selen i njurar, lever och tvärstrimmig muskulatur hos svin efter långvarig utfodring med terapeutiska doser natriumselenit

Summary

Sodium selenite was mixed in a commercial pig food so as to increase the original selenium content (0.126 ppm) by 1.2 ppm. The supplemented food was given to 7 pigs during 78 days. A control group of as many pigs was given the non-supplemented commercial food. The pigs were killed, starting 4 hours after the last selenium-supplemented food had been given and then with intervals during the next 14 days. Small but significant increases of tissue selenium were noticed in liver and striated muscle as compared with the control animals. The kidneys showed no increase.

Zusammenfassung

Natriumselenit wurde einem kommerziellen Schweinefutter beigemengt so dass das Gehalt (0.126 ppm) mit 1.2 ppm erhöht wurde. Das supplierte Futter wurde 7 Schweinen während 78 Tagen gegeben. Das unsupplierte kommerzielle Futter wurde einer Kontrollgruppe derselben Anzahl von Schweinen gegeben.

Die Schweine wurden getötet mit Beginn 4 Stunden nach dem letzten Füttern von selensuppliertem Futter und dann mit Intervallen während der nächsten 14 Tagen. Kleine aber signifikante Erhöhungen des Selens im Vergleich mit den Kontrollen wurden in der Leber und in querstreifiger Muskulatur gefunden. Die Nieren zeigten keine Erhöhungen.

Sammanfattning

Natriumselenit inblandades i ett kommersiellt svinfoder, så att den ursprungliga selenhalten (0.126 ppm) ökades med 1.2 ppm. Det supplementerade fodret gavs åt 7 griser under 78 dagar. En kontrollgrupp på lika många djur gavs det osupplementerade kommersiella fodret.

Grisarna dödades med början 4 timmar efter den sista utfodringen med selenberikat foder och därefter med intervaller under de följande 14 dagarna. Små men signifikanta stegringar av vävnadsselen observerades i lever och tvärstrimmig muskulatur. Njurarna visade ingen stegring.

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Correspondence to P. Lindberg.

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This investigation was supported by a grant from Jordbrukets Forskningsråd.

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Lindberg, P., Lannek, N. Retention of Selenium in Kidneys, Liver and Striated Muscle After Prolonged Feeding of Therapeutic Amounts of Sodium Selenite to Pigs. Acta Vet Scand 6, 217–223 (1965). https://doi.org/10.1186/BF03547078

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