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Passage of I131-Albumin and I125-Gamma Globulin Into the Small Intestine of Calves

Der intestinale Durchtritt von J131-Albumin und J125-Gammaglobulin

Udskillelse af J131-albumin og J125-gammaglobulin til tyndtarmen hos kalve

Summary

Intestinal transfer of I131-albumin and I125-gamma globulin was studied in 5 calves fitted with re-entrant intestinal loops. The passage of the two proteins across the intestinal wall proved highly variable (cf. Table II). However, the transfer of I131-albumin and I125-gamma globulin was of the same order of magnitude, which is taken as evideńce of similar transfer mechanisms of albumin and gamma globulin, in spite of different molecular weights. Instillations of hypertonic magnesium sulphate solution and of intestinal digesta were followed by increased transfer rates. It appears, therefore, that the passage of digesta will influence the transfer of proteins along the gut. It is emphasized that quantitation of the transfer as related to total catabolism of plasma proteins is subject to considerable inaccuracy.

Zusammenfassung

bei Kälbern.

Der intestinale Durchtritt von J131-Albumin und J125-Gammaglobulin bei 5 Kälbern mit isolierten Darmsegmenten wurde untersucht. Ausserordentliche Variation wurde festgestellt (Tabelle II), wogegen eine Vergleichung zwischen dem Durchtritt von Albumin und Gammaglobulin erwies, dass dieser von gleicher Grösse war. Dies wird als Schein daran gehalten, dass der Durchtritt von beiden Eiweissstoffen dem selben metabolischen Muster folgt, trotz verschiedenes Molekülgewicht. Instillationen von hypertonischen Magnesiumsulfatlösungen und von Ingesta rufen eine Steigerung im Durchtritt hervor. Es ist deshalb sehr wahrscheinlich, dass die Darmpassage für den Durchtritt von Plasmaproteinen dem Darm entlang eine Rolle spielt. Es wird betönt, dass die quantitative Berechnung des Durchtrittes in Relation zum totalen Eiweiss-Katabolismus unsicher ist.

Sammanfattning

Den intestinale udskillelse af J131-albumin og J125-gammaglobulin er undersøgt hos 5 kalve forsynede med isolerede tarmslynger. Der fandtes overordentlig stor variation i udskillelsen (tabel II), hvorimod en sammenligning mellem udskillelsen af albumin og gammaglobulin viste, at denne var af samme størrelsesorden. Dette er taget som udtryk for, at udskillelsen af de to proteinstoffer følger samme metaboliske mønster trods den forskellige molekylvægt. Instillation af hypertoniske magnesiumsulfatopløsninger samt af tyndtarmsindhold efterfulgtes af en forøget udskillelse af begge plasmaproteiner. Det må derfor anses for sandsynligt, at tarmpassagen spiller en rolle for udskillelsen af serumproteiner ned gennem tarmen. Det understreges, at beregninger af udskillelsens betydning i forhold til proteinnedbrydningen som helhed, er underkastet betydelig usikkerhed.

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Correspondence to Knud Nielsen.

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This investigation was aided by a grant from Statens almindelige Videnskabsfond

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Nielsen, K., Dich, J. Passage of I131-Albumin and I125-Gamma Globulin Into the Small Intestine of Calves. Acta Vet Scand 6, 249–260 (1965). https://doi.org/10.1186/BF03547082

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