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Retention of Selenium in Tissues of Swine After A Single Intramuscular Administration of Sodium Selenite

Die Retention von Selen in Geweben des Schweines nach einer intramuskulären Injektion von Natriumselenit

Retention av selen i vävnaderna av svin efter en intramuskulär injektion av natriumselenit

Summary

The retention of selenium in pigs after a single intramuscular administration of a preparation containing sodium selenite and alphatocopherol was studied.

At the site of injection the concentration fell from 0.8 ppm to normal 0.4 ppm in about a week.

The concentration in the liver was 4.47 ppm after 4 hours, 2.18–2.38 ppm after 3 days, and on normal level (about 1.5 ppm) after 7 days. No increase was observed in the kidney or in the M. gracilis. It is concluded that the liver probably plays an important excretory role.

Zusammenfassung

Die Retention von Selen bei Schweinen nach einer einmaligen intramuskulären Behandlung mit einem Preparat aus Natriumselenit und alpha-Tocopherol bestehend wurde untersucht. Die Konzentration am Injektionsplatz fiel von 0.8 p.p.m. zu normalen 0.4 p.p.m. während ungefähr einer Woche. In der Leber war die Konzentration 4.47 p.p.m. nach 4 Stunden, 2.18–2.38 p.p.m. nach 3 Tagen, und am normalen Niveau (ungefähr 1.5 p.p.m.)nach 7 Tagen. Die Verfasser ziehen den Schluss, dass die Leber eine wichtige Rolle als Ausscheidungsorgan spielt. In den Nieren und im M. gracilis wurde keine Erhöhung festgestellt.

Sammanfattning

Retentionen av selen hos grisar efter en intramuskulär administration av ett préparât innehållande natriumselenit och alfa-tokoferol har undersökts.

På injektionsplatsen föil koncentrationen från 0.8 ppm till normala 0.4 ppm under c:a 1 vecka.

Koncentrationen i levern var 4.47 ppm efter 4 timmar, 2.18–2.38 ppm efter 3 dygn, och på normal nivå (c:a 1.5 ppm) efter 7 dagar. Ingen stegring observerades i njurar eller M. gracilis. Författarna antar att levern spelar en viktig exkretorisk roll.

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Correspondence to P. Lindberg.

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This investigation was supported by Jordbrukets Forskningsråd

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Lindberg, P., Tanhuanpää, E. Retention of Selenium in Tissues of Swine After A Single Intramuscular Administration of Sodium Selenite. Acta Vet Scand 6, 268–273 (1965). https://doi.org/10.1186/BF03547084

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