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The Placental Transmission of Selenium in Sheep

Die Übertragung von Selen durch die Plazenta auf den Fötus beim Schaf

Överforing av selen via placenta hos får

Summary

The placental transmission of selenium was investigated in thirteen ewes during late gestation. The ewes were injected either with Se75-sodium selenite, Se75(L)-selenocystine or Se75 (L)-selenomethionine. Twelve lambs and nine ewes were killed soon after delivery and the Se75-concentration was measured in the tissues of the lambs and ewes.

The Se75-concentration in the tissues of the lambs was about half that of the ewes when they were injected with selenite. This indicates that the placenta constitutes to a certain extent a barrier for the passage of inorganic selenium. Se75-selenomethionine and Se75-selenocystine were more easily transferred across the placenta than Se75-sodium selenite. When the selenite dose was increased ten times the selenium uptake in milligrams per gram tissue in the lambs increased 5–8 times.

Zusammenfassung

Die Übertragung des Selens auf den Fötus wurde bei dreizehn hochträchtigen Mutterschafen untersucht. Den Mutterschafen wurde entweder Se75-Natriumselenit (zwei verschiedene Dosen: 0,48 oder 5,1 mg Se), Se75-Selencystin oder Se75-Selenmethionin subkutan injiziert. Zwölf Lämmer und neun Mutterschafe wurden gleich nach dem Partus getötet und die Se75-Konzentration in den Geweben der Lämmer und der Mutterschafe gemessen.

Als den Mutterschafen Selenit injiziert wurde, betrug die Se75-Konzentration in den Geweben der Lämmer ungefähr die Hälfte der in den Geweben der Mutterschafe vorhandenen. Dies deutet darauf hin, dass die Plazenta ein gewisses Hindernis für die Passage anorganischen Selens von der Mutter zum Fötus bildet. Se75-Selenmethionin und Se75-Selencystin passierten die Plazenta leichter als Selenit. Die Se75-Konzentration bei den Lämmern war hier in den meisten Organen ebenso hoch und in gewissen Organen sogar noch höher als bei den Mutterschafen.

Wurde die Selenitdosis zehnfach erhöht, so nahm der Selenzuschuss in den Geweben der Lämmer fünf- bis achtmal zu, in Milligram Se pro Gramm Gewebe gerechnet.

Sammanfattning

Överforingen av selen till foster un der söktes på tretton högdräktiga tackor. Tackorna injicerades subkutant antingen med Se75-natrium-selenit (två olika doser: 0,48 eller 5,1 mg Se), Se75-selencystin eller Se75-selenmetionin. Tolv lamm och nio tackor avlivades strax efter förlossningen och Se75-koncentrationen mattes i lammens och tackornas vävnader.

När tackorna injicerades med selenit var Se75-koncentrationen i lammens vävnader omkring hälften av den i tackornas. Detta tyder på att placentan utgör ett visst hinder för det oorganiska selenets passage från moder till foster. Se75-selenmetionin och Se75-selencystin passerade placentan lättare än selenit. Se75-koncentration hos lammen var då i de fiesta organ nästan lika hög som och i vissa organ högre an hos tackorna.

När selenitdosen ökade tio ganger ökade selentillskottet i lammens vävnader fem till åtta ganger räknat i milligram Se per gram vävnad.

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This investigation was supported by grant from the Swedish Agricultural Research Council.

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Jacobsson, S.O., Oksanen, H.E. The Placental Transmission of Selenium in Sheep. Acta Vet Scand 7, 66–76 (1966). https://doi.org/10.1186/BF03547098

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