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Transaminase and Transferase Activities in Blood Plasma and Tissues in Dogs

Transaminase- und Transferaseaktiuität der Plasma und verschiedener Geweben beim Hunde

Transaminas- och transferasaktiviteten i blodplasma och olika väunader hos hund

Summary

The levels of glutamic-oxaloacetic transaminase (G.O.T.), glutamicpyruvic transaminase (G.P.T.), and ornithine-carbamyl transferase (O.C.T.) were studied in different organs from healthy dogs. In the liver the activity of G.O.T., G.P.T., and O.C.T. was high. In the heart the G.O.T. level was high, the G.P.T. level lower, and the O.C.T. level very low. The skeletal muscles were found to have a very high G.O.T. level and very low levels of G.P.T. and O.C.T.

The plasma-enzyme activities were determined in healthy dogs. Mean values (x̅), standard deviations (s. d.), and the number of dogs (n) are tabulated below.

A close correlation could be demonstrated between the values for G.P.T. and O.G.T. These two enzymes have their highest activity in the liver and should therefore be useful in the diagnosis of liver damage; together with G.O.T. they should also be of value in the differential diagnosis between hepatic damage and lesions of the heart and muscles.

Zusammenfassung

Die Enzymikoncentrationen von GOT (Glutaminsäure-Oxalessigsäure Transaminase), GPT (Glutaminsäure-Pyrotraubensäure Transaminase) und OCT (Ornithin Karbamyl Transferase) in verschiedenen Organen von normalen Hunden wurden untersucht. Die Leber enthält grosse Mengen von GOT, GPT und OCT. Das Herz enthält soeben grosse Mengen von GOT, aber weniger GPT und sehr wenig OCT. In der Skeletmuskulatur ist GOT reichlich vorhanden, der Gehalt an GPT und OCT ist dagegen sehr klein.

Die Enzymkoncentrationen in der Plasma wurden für normale Hunde bestimmt. Die Mittelwerte (x̅), Standard-Abweichungen (s.d.) und die Anzahl der Hunden (n) sind wie folgt angegeben:

Eine ausgeprägte Korrelation zwischen den Werten für GPT und OCT konnte nachgewiesen werden. Da diese zwei Enzymen die grösste Aktivität in der Leber entfalten, können bei der Diagnostik der Leberbeschädigungen von Bedeutung sein und können zusammen mit GOT die Differential-Diagnose zwischen den Leberbeschädigungen einerseits und Herz- bzw. Skelettmuskelbeschädigungen anderseits, erleichtern.

Sammanfattning

Enzymkonoenibrationerna av GOT CglutaminsyreK)xalättiksyretransaminas) GPT (glutaminsyre-pyrodruvsyretransaminas) och OCT (Ornithin oarbamid-transferas) har undersökts i olika organ från normala hundar. Levern innehåller stora mängder av saväl GOT, GPT som OCT. Hjärtat har höga koncentrationer av GOT, mindre av GPT och mycket lite OCT. Skelettmuskulaturein är mycket rik på GOT men mycket fattig på GPT och OCT.

Enzymkoncentrationerna i plasma har bestämts för nørmala hundar. Nedan anges medelvärdena (x̅), standardawikelser (s.d.) och antalet hundar (n)

Stark korrelation kunde visas mellan varden for GPT och OCT. Dessia två enzymer har sin största aktivitet i levern och bör därför äga diagnostisk betydelse vid leverskador ooh tillsammans med GOT vara till hjälp vid differentialdiagnostiseringar mellan dessa och hjärtooh muskelskador.

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Lindblad, G., Persson, F. Transaminase and Transferase Activities in Blood Plasma and Tissues in Dogs. Acta Vet Scand 3, 367–377 (1962). https://doi.org/10.1186/BF03547149

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