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Transaminase and Transferase Activities in Blood-Plasma of Dogs with Experimentally Produced Hepatitis Contagiosa Canis (H.C.C.)

Transaminase- und Transferaseaktiuität der Plasma bei Hunden mit experimentell erzeugter H.c.c. (Hepatitis contagiosa canis)

Transaminas- och transferasaktiviteten i blodplasma hos hundar med experimenteilt framkallad H.c.c. (Hepatitis contagiosa canis)

Acta Veterinaria Scandinavica volume 3, pages 378–390 (1962)Cite this article

Summary

Continuous and comparative studies of the plasma-levels of glutamic-oxaloacetic transaminase (G.O.T.), glutamic-pyruvic transaminase (G.P.T.), and ornithine-carbamyl transferase (O.C.T.), as well as the concentration of bromsulphalein (B.S.P.) showed that in experimentally produced hepatitis contagiosa canis (H.c.c.) the plasma-activity of these enzymes and B.S.P. retention were raised and the increased B.S.P. retention correlated in time with the rises in plasmaenzyme activity.

A marked leucopenia developed simultaneously with temperature elevations. The lymphocyte/neutrophil ratio changed towards an increase in lymphocytes during the disease.

Electrophoretic studies of serum-proteins showed a rise of γ-globulins and a corresponding decrease of the albumins, that is, an unchanged level of total protein.

Zusammenfassung

Kontinuierliche und vergleichende Untersuchungen über die Plasma-Aktivität von Glutaminsäure-Oxalesisigsäure Transaminase (GOT), Glutaminsäure-Pyrotraubensäure Transaminase (GPT) und Ornithin Karbamyl Transferase (OCT) als auch die Konzentration von Bromsulf alein (BSP), zeigten bei experimentell erzeugter Hepatitis contagiosa canis (Hcc), dass die Plasma-Aktivität dieser Enr zymen und die BSP Retention anstieg und dass die erhöhte BSP Retention mit den gleichzeitigen Erhöhungen der Plasma-Enzymen Aktivität üb er einstimmte.

Eine ausgeprägte Leukopenie entwickelte sich gleichzeitig mit den Temperatursteigerungen. Das Verhältnis zwischen den Lymphozyten und Neutrophilen hat sich während der Krankheit zu der Lymphozyten verschoben.

Elektrophoretisohe Untersuchungen der Serumproteinen zeigten eine Erhöhung der γ-Globulinen und eine entsprechende Senkung der Albuminen, also einen unveränderten Totalproteingehalt.

Sammanfattning

Förf attarna har gjort kontinuerliga och jämföranide undersökningar av plasmaaktiviteten av GOT (glutaminsyre-Oxalättiksyretransaminas) GPT (glutaminsyre-pyrodruvsyretransaminas) OCT (Ornithin carbamyltransferas), samt BSP (bromsulfaleinretention) och funmit dessa förhöjda och tidmässigt korrelerade vid experimentell hepatitis contagiosa canis (H.c.c).

En uttalad leukopeni intrader samtidigt med temperaturstegring. Förhallandet lymfocyter-neutrofila leukocyter ökar under sjukdomen.

Elektroforetisik undersökning av serumproteinerna har visat en γ-globulinökning och motsvarande minskning av albuminerna, d. v. s. oförändrat totalprotein.

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Authors
  1. G. Lindblad
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  2. F. Persson
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Lindblad, G., Persson, F. Transaminase and Transferase Activities in Blood-Plasma of Dogs with Experimentally Produced Hepatitis Contagiosa Canis (H.C.C.). Acta Vet Scand 3, 378–390 (1962). https://doi.org/10.1186/BF03547150

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Acta Veterinaria Scandinavica

ISSN: 1751-0147