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The Volume of Distribution of Sodium Thiosulphate as a Measure of the Extra-Cellular Fluid Space in Suckling Pigs

Der Verteilungsvolumen des Natrium-Thiosulphat als Masstab für den extracellulären Flüssigkeitraum bei Säuglingsferkeln

Distributionsvolymen av natriumtiosulfat som ett mått på extracellulära vätskerummet hos diande grisar

Acta Veterinaria Scandinavica volume 4, pages 97–112 (1963)Cite this article

Summary

The extracellular fluid space (EFS) was determined using the thiosulphate method. One litter of piglets was used for the experiment, which comprised repeated determinations during the first 6 weeks of life. The mean EFS gradually fell from 34 % of the body-weight at the age of 6 days to about 28 % at the age of 41 days. The reproducibility of the method was tested by two determinations, one four hours after the other, on each of 11 piglets. Before 4 of the second determinations the renal vessels were ligated. The results were on the whole consistent. Large variations occurred in individual pigs from time to time and between pigs of the same age.

Zusammenfassung

Der extracelluläre Flüssigkeitraum wurde mit der Thiosulphat-Methode bestimmt. Ein Wurf Ferkeln wurde während der sechs ersten Lebenswochen wiederholt untersucht. Der Flüssigkeitsraum betrug c: a 34 % des Körpergewichtes bei sechstägigen Ferkeln und verminderte sich bis 28 % bei 41 Tage alten Ferkeln. Zwei Bestimmungen mit einem Zeitunterschied von vier Stunden wurden bei elf Ferkeln vorgenommen. Vor den Bestimmungen aus der zweiter Reihe wurden bei vier die Nierengefässe unterbunden. Hauptsächlich zeigten die Ergebnisse eine gute Übereinstimmung. Grosse Variationen kamen vor bei einzelnen Ferkeln bei verschiedenen Untersuehungsgelegenheiten als auch zwischen den gleichaltrigen Ferkeln.

Sammanfattning

Den extracellulära vätskevolymen bestämdes i enlighet med tiosulfatmetoden. En kull grisar följdes genom upprepade bestämningar under de 6 första levnadsveckorna. Vätsikevolymen minskade från c:a 34 % av kroppsvikten vid 6 dagars ålder till omkring 28 % vid 41 dagars ålder. Metoden kontrollerades genom att två bestämniingar med 4 timmars mellanrum utfördes på vardera av 11 grisar. Före 4 av andra-bestämningarna ligerades njurkärlen. Resultaten visade i stort sett god överenstämmelse. Stora variationer förefanns hos en och samma gris vid olika undersökningstillfällen liksom mellan lika gamla grisar.

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  1. Medical Department of the Royal Veterinary College, Stockholm, Sweden

    Gunnar Tollerz

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  1. Gunnar Tollerz
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Mebumal consists of 5:ethyl-5 (1-methylbutyl)-malonyl carbamide (Pentobarbitone), 1.8 g.; pentobarbitone sodium, 4.0 g.; urethane, 25.0 g.; 96 % ethanol, 15.0 g.; glycerol, 125 g.; sterile water to make 100 ml.

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Tollerz, G. The Volume of Distribution of Sodium Thiosulphate as a Measure of the Extra-Cellular Fluid Space in Suckling Pigs. Acta Vet Scand 4, 97–112 (1963). https://doi.org/10.1186/BF03547176

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Acta Veterinaria Scandinavica

ISSN: 1751-0147