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Studies on the Virus of Hepatitis Contagiosa Canis (HCC)

III. The Viraemic Phase of Hcc Virus Infection in Guinea Pigs

Studien über das Virus des Hepatitis Contagiosa Canis (HCC)

III. Die Viraemische Phase der HCC-Virus Infektion bei Meerschweinchen

Studier över Hepatitis Contagiosa Canis virus (HCC)

III. Virämiskedet vid HCC virus infektion hos marsvin

Acta Veterinaria Scandinavica volume 4, pages 356–370 (1963)Cite this article

Summary

The distribution of virus during the viraemia phase of HCC infection in guinea pigs was studied. It was found that the virus was bound to the mononuclear white blood cells.

Antibody titration revealed that several of the animals with viraemia had HCC antibodies in serum.

By an indirect method it was shown that a virus inhibitor appeared in the blood between 2–3 days after inoculation. Its effect gradually increased as long as virus titrations could be performed with certainty as to mean titre value.

Zusammenfassung

Die Virusverteilung wurde in Hinsicht auf verschiedene Blutfraktionen und Blutzellen untersucht. Es wurde gefunden, dass das Virus an die weissen mononucleären Zellen gebunden war.

Eine Anzahl Tiere mit Viraemie besass gleichzeitig Antikörper gegen das Virus im Serum.

Mit Hilfe eine indirekten Methode konnte gezeigt werden, dass ein Virusinhibitor 2–3 Tage nach der Impfung im Blute auftrat. Diese nahm kontinuierlich zu und dies so lange, als Virustitrierungen mit einiger Sicherheit rücksichtlich Mittel-Titer-Wert durchgeführt werden konnten.

Sammanfattning

Fördelningen av virus under virämiskedet med hänsyn till olika blodfraktioner och blodceller undersöktes. Det befanns att virus var bundet till de vita mononukleära cellerna.

Ett flertal djur med virämi hade samtidigt antikroppar mot virus i sina serum.

Genom indirekt metodik kunde det visas, att en virusinhibitor uppträdde i blodet 2–3 dagar efter ympningen. Dess effekt ökade kontinuerligt och så länge som virustitreringar kunde göras med någorlunda säkerhet med hänsyn till titermedelvärde.

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  1. State Bacteriological Laboratory and the Department of Virus Research, Caroline Institute, School of Medicine, Stockholm, Sweden

    C. R. Salenstedt

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Salenstedt, C.R. Studies on the Virus of Hepatitis Contagiosa Canis (HCC). Acta Vet Scand 4, 356–370 (1963). https://doi.org/10.1186/BF03547196

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Acta Veterinaria Scandinavica

ISSN: 1751-0147