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Studies on the Virus of Hepatitis Contagiosa Canis (HCC)

IV. The Pathogenesis of Hepatitis Contagiosa Canis in Dogs

Studien über das Virus des Hepatitis Contagiosa Canis (HCC)

IV. Die Pathogenese von Hepatitis Contagiosa Canis bei Hunden

Studier över Hepatitis Contagiosa Canis virus (HCC)

IV. Patogenesen vid Hepatitis Contagiosa Canis hos hundar

Summary

The pathogenesis of HCC virus infection in the dog has been investigated. Dogs were infected with virus given per os. After multiplication in the tonsils and in the draining lymph nodes virus was carried to the blood via the cervical lymph vessels. Virus was also absorbed to cells in the wall of the small intestine. In those cells as well as in the draining lymph nodes a multiplication took place and virus was then brought to the blood by the lymph in vessels from the mesenteric lymph nodes and via ductus thoracicus. By the blood virus was spread over the whole body and was detected in several organs among them the liver. This was shown 3–5 days after virus was detected in the tonsils. It was also demonstrated that dogs could be infected when the virus was given in gelatine capsules. The tonsils thus were excluded from possibility to absorb virus and the infection probably was initiated by absorbtion of the virus to cells in the small intestine.

Zusammenfassung

Eine Untersuchung in Bezug auf die Pathogenese der HCC beim Hunde wurde unternommen. Die Tiere wurden per os mit Virus infiziert. Nach einer Vermehrung in den Tonsillen und regionalen Lymphknoten gelangte das Virus über die Halslymphgefässe in den Blutkreislauf. Es wurde des weiteren an Zellen der Dünndarmwand absorbiert. In diesen Zellen wie auch in den regionalen Lymphdrüsen fand eine Virusvermehrung statt. Von dort aus gelangte der Infektionsstoff über Lymphgefässe der Mesenteriallymphknoten via ductus thoracicus in den Blutkreislauf. Mit dem Blute wurde das Virus im Gesamtorganismus verteilt und konnte in mehreren Organen, u. a. in der Leber nachgewiesen werden. Dies geschah 3–5 Tage nachdem das Virus in den Tonsillen festgestellt worden war. Es konnte weiterhin gezeigt werden, dass die Hunde auch mittels Virus in Gelatinekapseln per os infiziert werden konnten.

Mittels diese Methode konnte die Möglichkeit einer Absorption von Virus an die Tonsillen ausgeschlossen werden. Daraus ist zu schliessen, dass die Infektion durch das Virus nach dessen Absorption an Zellen der Dünndarmwand initiiert wurde.

Sammanfattning

En undersökning över patogenesen vid HCC hos hund genomfördes. Hundarna infekterades med virus per os. Efter förökning i tonsillerna och i de regionära lymfkörtlarna fördes virus via halslymfkärl till blodet. Virus absorberades även till celler i tunntarmsväggen. I dessa celler ävensom i tarmens regionära lymfkörtlar ägde en virus-förökning rum. Därifrån fördes infektionsämnet med lymfkärl från mesenteriallymfkörtlarna via ductus thoracicus till blodet. Med detta spreds virus över hela organismen och kunde påvisas i flera organ bl. a. i levern. Detta inträffade 3–5 dagar efter det att virus hade upptäckts i tonsillerna. Det kunde också visas att hundarna infekterades även då virus tillfördes per gelatinkapslar. Då så skedde uteslöts möjligheten för absorbtion av virus till tonsillerna. Infektionen bör då ha initierats genom att virus absorberats till celler i tunntarmsväggen.

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Salenstedt, C.R. Studies on the Virus of Hepatitis Contagiosa Canis (HCC). Acta Vet Scand 4, 371–383 (1963). https://doi.org/10.1186/BF03547197

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