- Published:
The Effects of Insulin, Glucose and Catecholamines on Some Blood Minerals in Sheep
Effekten au insulin, glykos och katekolaminer på några blodmineraler hos får
Acta Veterinaria Scandinavica volume 15, pages 519–532 (1974)
Abstract
Intravenous injection of insulin, 0.5 i.u./kg, was followed by a decrease in plasma magnesium. It is earlier known that insulin sometimes lowers the blood magnesium level, and the mechanism behind this effect is said to be an increased tissue uptake of magnesium. Glucose infusion did not change plasma magnesium, whereas norepinephrine and epinephrine caused a slight reduction. Insulin at the dose of 1 i.u./kg reduced plasma calcium in intact sheep. In thyroidectomized sheep the same dose caused a rise in plasma calcium. It is suggested that insulin caused hypercalcaemia in the thyroidectomized sheep by increasing the rate of bone resorption, and that the decrease in plasma calcium observed in the intact sheep was due to release of calcitonin to such an extent that the bone resorbing effect of insulin was blocked. Insulin also lowered plasma inorganic phosphorus in the thyroidectomized sheep.
Sammanfattning
Intravenös injektion av insulin (0,5 I.U./kg) på får medförde en signifikant hypomagnesemi. Det har tidigare observerais att insulin under vissa betingelser har en hypomagnesemisk effekt och förklaringen anses vara ett ökat vävnadsupptag av magnesium. Glykosinfusion påverkade inte plasmamagnesium, däremot medförde noradrenalin och adrenalin en lindring sänkning. Intravenös injektion av insulin (1 I.U./kg) medförde pà intakta får hypokalcemi. Samma dos insulin gav på thyreoidektomerade får en stegring i kalciumkoncentrationen. Hyperkalcemin hos dessa antas bero på att insulin ökar benresorptionen medan hypokalcemin hos de intakta djuren sannolikt beror på en ökad frisättning av endogent kalcitonin i sådan omfattning att insulinets effekt på benresorptionen blockeras. Insulin medförde dessutom hypofosfatemi hos thyreoidektomerade får.
References
Aikawa, J. K.: Effect of glucose and insulin on magnesium metabolism in rabbits. A study with Mg28. Proc. Soc. exp. Biol. (N.Y.) 1960, 103, 363–366.
Aikawa, J. K.: The role of magnesium in biologic processes. Charles C. Thomas, Publisher. Springfield, Illinois 1963.
Akgün, S. & D. Rudman: Relationships between the mobilization of free fatty acids from adipose tissue, and the concentration of calcium in the extracellular fluid and in the tissue. Endocrinology 1969, 84, 926–930.
Alm, B., S. Efendic & H. Löw: Effect of lipolytic and antilipolytic agents on the uptake of 47Ca into rat adipose tissue in vitro. Horm. Metab. Res. 1970, 2, 142–146.
Buckle, R. M., A. D. Care, C. W. Cooper & H. J. Gitelman: The influence of plasma magnesium concentration on parathyroid hormone secretion. J. Endocr. 1968, 42, 529–534.
Burt, R. L.: Carbohydrate metabolism in pregnancy. Clin. Obstet. Gynec. 1960, 3, 310–325.
Care, A. D., L. M. Sherwood, J. T. Potts Jr. & G. D. Aurbach: Perfusion of the isolated parathyroid gland of the goat and sheep. Nature (Lond.) 1966, 209, 55–57.
Cier, J. F. & J. Klipping (1956). Cited by Natelson, S., J. B. Pincus & G. Rannazzisi: Dynamic control of calcium, phosphate, citrate and glucose levels in blood serum. Clin. Chem. 1963, 9, 31–62.
Classen, H., G. P. Marquardt, M. Späth & K. A. Schumacher: Hypermagnesemia following exposure to acute stress. Pharmacology 1971, 5, 287–294.
Conte, N., G. Federspil, S. Frezzato, A. Trisotto, C. Scandellari & G. Piemonte: Glucagon effect on plasma Mg concentration. Horm. Metab. Res. 1972, 4, 48–50.
Cooper, C. W., W. H. Schwesinger, A. M. Mahgoub, D. A. Ontjes, T. G. Gray & P. L. Munson: Regulation of secretion of thyrocalcitonin. In Calcium, Parathyroid Hormone and the Calcitonins. Eds. R. V. Talmage & P. L. Munson. Excerpta Medica, Amsterdam 1972.
Croughs, W., W. Schopman & H. A. W. Tiddens: Plasma growth hormone response to insulin-induced hypoglycemia. Helv. paediat. Acta 1968, 23, 464–477.
Dole, V. P.: A relation between non-esterified fatty acid in plasma and the metabolism of glucose. J. clin. Invest. 1956, 35, 150–154.
Gilbert, D. L.: Effect of pH on muscle calcium and magnesium. Proc. Soc. exp. Biol. (N.Y.) 1961, 106, 550–552.
Gill, J. R. Jr., H. B. Bell & F. C. Bartter: Effect of parathyroid extract on magnesium excretion in man. J. appl. Physiol. 1967, 22, 136–138.
Greenwood, F. C., J. Landon & T. C. B. Stamp: The plasma sugar, free fatty acid, Cortisol, and growth hormone response to insulin. I. In control subjects. J. clin, Invest. 1966, 45, 429–436.
H anna, S. & I. MacIntyre: The influence of aldosterone on magnesium metabolism. Lancet 1960, 2, 348–350.
Heaton, F. W.: The parathyroid glands and magnesium metabolism in the rat. Clin. Sci. 1965, 28, 543–553.
Krishna, G., S. Hynie & B. B. Brodie: Effect of thyroid hormones on adenyl cyclase in adipose tissue and on free fatty acid mobilization. Proc. nat. Acad. Sci. (Wash.) 1968, 59, 884–889.
Larvor, P.: Effet de l’adrénaline et de la noradrénaline sur la magnésémie et la glycémie du rat. Interference de la dihydroergotamine et de l’insuline. (Effect of epinephrine and norepinephrine on the blood levels of glucose and magnesium in the rat. Influence of dihydroergotamine and insulin). Ann. Biol. anim. 1968, 8, 461–464.
Larvor, P. & Y. Rayssiguier: Les récepteurs responsables de l’hypermagnésémie consécutive a une injection de catécholamines. (Determination of the receptors responsible for catecholamine-induced hypermagnesemia). Ann. Biol. anim. 1971, 11, 55–68.
Luthman, J. & G. Jonson: Short-term hormonal effects on blood glucose and non-esterified fatty acids in female sheep. Acta vet. scand. 1972, 13, 112–127.
Luthman, J. & J. Persson: The hypocalcaemic effect of toluidine blue in sheep. Zbl. Vet.-Med. A. 1974, 21, 89–95.
Luthman, J., G. Jonson & J. Persson: Studies on norepinephrine-induced hypocalcemia in sheep before and after thyroidectomy. Acta vet. scand. 1972, 13, 20–30.
Meyer, H. & P. Schmidt: Der Einfluss von Thyroxin auf den Magnesium- und Kalziumstoffwechsel beim Kalb. (The influence of thyroxin on magnesium and calcium metabolism in the calf). Dtsch. tierärztl. Wschr. 1958, 65, 602–604.
Moseley, G. & R. F. E. Axford: Redistribution of calcium in sheep induced by stress. Proc. Nutr. Soc. 1971, 30, 58A.
Puche, R. C., M. C. Romano, M. E. Locatto & J. L. Feretti: The effect of insulin on bone resorption. Calcif. Tiss. Res. 1973, 12, 8–15.
Rayssiguier, Y. & P. Larvor: Hypermagnésémie et sécrétion médullosurrénalienne. (Hypermagnesemia and secretion of the adrenal medulla). Ann. Biol. anim. 1972, 12, 479–491.
Robinson, G. A., R. W. Butcher & E. W. Sutherland: Cyclic AMP. Ann. Rev. Biochem. 1968, 37, 149–174.
Roth, J., S. Glick, R. S. Yalow & S. A. Berson: Hypoglycemia: A potent stimulus to secretion of growth hormone. Science 1963, 140, 987–988.
Scott, D. & A. Dobson: Aldosterone and the metabolism of magnesium and other minerals in the sheep. Quart. J. exp. Physiol. 1965, 50, 42–56.
Skerry, D. W.: Di-(2-hydroxy-phenyl-imino)ethane: A new indicator for the EDTA titration of serum calcium. Clin. chim. Acta 1965, 12, 593–597.
Stadil, F. & J. F. Rehfeld: Hypoglycaemic release of gastrin in man. Scand. J. Gastroent. 1972, 7, 509–514.
Trenkle, A.: Influence of blood glucose levels on growth hormone secretion in sheep. Proc. Soc. exp. Biol. (N.Y.) 1971, 136, 51–55.
Wacker, W. E. C. & A. F. Parisi: Magnesium metabolism. New Engl. J. Med. 1968, 278, 712–717.
Walser, M.: Magnesium metabolism. Ergebn. Physiol. 1967, 59, 185– 296.
Whang, R., D. Wagner & D. Rodgers: The effect of intravenous insulin and glucose on serum Mg and K concentration. Clin. Res. 1966, 14, 390.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Persson, J., Luthman, J. The Effects of Insulin, Glucose and Catecholamines on Some Blood Minerals in Sheep. Acta Vet Scand 15, 519–532 (1974). https://doi.org/10.1186/BF03547223
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1186/BF03547223