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The Effects of Insulin, Glucose and Catecholamines on Some Blood Minerals in Sheep

Effekten au insulin, glykos och katekolaminer på några blodmineraler hos får

Acta Veterinaria Scandinavica volume 15, pages 519–532 (1974)Cite this article

Abstract

Intravenous injection of insulin, 0.5 i.u./kg, was followed by a decrease in plasma magnesium. It is earlier known that insulin sometimes lowers the blood magnesium level, and the mechanism behind this effect is said to be an increased tissue uptake of magnesium. Glucose infusion did not change plasma magnesium, whereas norepinephrine and epinephrine caused a slight reduction. Insulin at the dose of 1 i.u./kg reduced plasma calcium in intact sheep. In thyroidectomized sheep the same dose caused a rise in plasma calcium. It is suggested that insulin caused hypercalcaemia in the thyroidectomized sheep by increasing the rate of bone resorption, and that the decrease in plasma calcium observed in the intact sheep was due to release of calcitonin to such an extent that the bone resorbing effect of insulin was blocked. Insulin also lowered plasma inorganic phosphorus in the thyroidectomized sheep.

Sammanfattning

Intravenös injektion av insulin (0,5 I.U./kg) på får medförde en signifikant hypomagnesemi. Det har tidigare observerais att insulin under vissa betingelser har en hypomagnesemisk effekt och förklaringen anses vara ett ökat vävnadsupptag av magnesium. Glykosinfusion påverkade inte plasmamagnesium, däremot medförde noradrenalin och adrenalin en lindring sänkning. Intravenös injektion av insulin (1 I.U./kg) medförde pà intakta får hypokalcemi. Samma dos insulin gav på thyreoidektomerade får en stegring i kalciumkoncentrationen. Hyperkalcemin hos dessa antas bero på att insulin ökar benresorptionen medan hypokalcemin hos de intakta djuren sannolikt beror på en ökad frisättning av endogent kalcitonin i sådan omfattning att insulinets effekt på benresorptionen blockeras. Insulin medförde dessutom hypofosfatemi hos thyreoidektomerade får.

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  1. Department of Medicine II, Royal Veterinary College, S-104 05, Stockholm 50, Sweden

    Jan Persson & Jan Luthman

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  1. Jan Persson
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Persson, J., Luthman, J. The Effects of Insulin, Glucose and Catecholamines on Some Blood Minerals in Sheep. Acta Vet Scand 15, 519–532 (1974). https://doi.org/10.1186/BF03547223

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Acta Veterinaria Scandinavica

ISSN: 1751-0147