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The Toxic Effects of Dimethylnitrosamine In Sheep
Toksisk virkning au dimethylnitrosamin på sau
Acta Veterinaria Scandinavica volume 15, pages 533–543 (1974)
Abstract
Experimental feeding, dealing with long term ingestion of small daily doses of DMNA has clearly demonstrated the cumulative toxic effect of this compound in sheep. A threshold level, somewhere between 0.10 mg and 0.15 mg DMNA/kg body weight per day, can be defined below which no toxicity even in quite long-lasting feeding can be demonstrated. Above this level toxicity changes will develop, clinically in most cases, anatomically in all, if the exposure time is long enough. If the daily intake of DMNA is over this threshold level, 21–40 mg DMNA/kg body weight, it usually causes liver disease and death in sheep. Neoplastic lesions were not produced, the experimental period, however, was below the latency period for carcinogenesis.
Sammendrag
Foringsforsøk har vist at daglig opptak av dimethylnitrosamin (DMNA) har en kumulativ toksisk effekt på sau hvis dagsdosene er over en terskelverdi på ca. 0,1–0,15 mg DMNA/kg levende vekt, mens dagsdoser mindre enn denne terskelverdi ikke ga kliniske symptomer eller pato-anatomiske forandringer. Dagsdoser over terskelverdien forårsaket toksiske forandringer, spesielt i leveren, leverinsuffisiens og d0d når dyret har opptatt 21–40 mg DMNA/kg levende vekt. Svulster forekom ikke på forsøkssauene, men forsøkstiden var langt under den latensperiode som en må forvente for svulstdanneise.
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Koppang, N. The Toxic Effects of Dimethylnitrosamine In Sheep. Acta Vet Scand 15, 533–543 (1974). https://doi.org/10.1186/BF03547224
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DOI: https://doi.org/10.1186/BF03547224