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Effects of Prostaglandin E2, Prostaglandin F2α and Endotoxin on Plasma Calcium Levels in The Goat

Effekter av PGE2, PGF2α och endotoxin på plasma Ca-nivåerna hos get.

Acta Veterinaria Scandinavica volume 25, pages 378–384 (1984)Cite this article

Abstract

Intravenous administration of 2.6–3.3 µg/kg of an endotoxin from Salmonella typhimurium to goats caused a marked drop in plasma Ca levels associated with an increase of prostaglandin synthesis and release measured as peripheral plasma levels of 15-keto-13,14-dihydro-PGF2 α. This is one of the main metabolites of PGF2 α, but also PGE2 α is partly metabolised to this compound. The infusion of 10 mg of PGF2 α lowered plasma Ca levels. Ten mg of PGE2 did not change Ca concentrations significantly.

Sammanfattning

Ett endotoxin från Salmonella typhimurium gavs iv till getter i doser om 2,6–3,3 µg/kg. Plasma Ca-nivåerna sjönk med ca 20 % under de första 5–10 timmarna för att efter 2–3 dagar långsamt öka och nå ursprungskoncentrationer efter 7–8 dagar. Höga nivåer av 15-keto-13,14-dihydro-PGF2α uppmättes under ca 20 timmar efter injektionen. Detta är en av huvudmetaboliterna till PGF2α, men också PGE2 metaboliseras i mindre omfattning till denna förening. När 10 mg PGF2α gavs iv under en timme erhölls en övergående sänkning av Canivåerna. Då PGE2 gavs på mots varan de sätt påverkades inte plasma Ca-koncentrationerna påtagligt.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Swedish University of Agricultural Sciences, Uppsala, Sweden

    Gunnar Fredriksson, Hans Kindahl & Lars-Eric Edqvist

  2. Department of Clinical Chemistry, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden

    Gunnar Fredriksson, Hans Kindahl & Lars-Eric Edqvist

Authors
  1. Gunnar Fredriksson
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  2. Hans Kindahl
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  3. Lars-Eric Edqvist
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Additional information

This study was supported by grants from the Swedish Council for Forestry and Agricultural Research.

We also want to thank the Upjohn Company for their generous gift of PGE2.

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Fredriksson, G., Kindahl, H. & Edqvist, LE. Effects of Prostaglandin E2, Prostaglandin F2α and Endotoxin on Plasma Calcium Levels in The Goat. Acta Vet Scand 25, 378–384 (1984). https://doi.org/10.1186/BF03547252

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  • DOI: https://doi.org/10.1186/BF03547252

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Acta Veterinaria Scandinavica

ISSN: 1751-0147