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Colostral Growth Factors
Possible Role in Bovine Udder Epithelial Cell Regeneration
Tillväxtstimulerande faktorer i kolostrum: möjlig roll i epitelcellregenerationen i kojuver.
Acta Veterinaria Scandinavica volume 33, pages 197–203 (1992)
Abstract
Growth of the secretory epithelium during prepartum time, and for a short period after calving, is under hormonal control by estrogen, progesterone and prolactin. The mechanism(s) by which these hormones act is not known but colostrum and milk have been shown to contain different growth promoting substances. In an attempt to unravel these relationships the effect of bovine colostrum on cellular proliferation in vitro have been characterized. Colostral thermostabile factors not present in milk nor associated with fat, potently induce the proliferation associated enzyme, ornithine decarboxylase, in fibroblast cell lines. However, mammary epithelial cells appear to proliferate in response to different colostral heat sensitive factor(s) that await further characterization.
Sammandrag
Det sekretoriska epitelets tillväxt i juvret under prepartum och en kort period efter kalvinigen står under hormonal kontroll genom estrogen, progesteron och prolaktin. De mekanismer genom vilka dessa hormoner utövar sin verkan är ej kända, men kolostrum och mjölk har påvisats innehålla tillväxtstimulerande faktorer. I ett försök att komma till klarhet med dessa mekanismer har vi studerat effekten av kolosrum från ko på cellers tillväxt in vitro. Kolostrala värmestabila faktorer, ej närvarande i mjölk eller associerade med fett, inducerar i fibroblastcellinjer en kraftig ökning i aktiviteten av ornitindekarboxylas, som är ett tillväxtassocierat enzym. Men epiteliala celler i juvret verkar även känna igen andra, ännu inte karaktiserade faktorer i kolostrum.
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Iivanainen, A., Hölttä, E., Ståhls, A. et al. Colostral Growth Factors. Acta Vet Scand 33, 197–203 (1992). https://doi.org/10.1186/BF03547309
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DOI: https://doi.org/10.1186/BF03547309