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Ketamine, Telazol®, Xylazine and Detomidine

A Comparative Anesthetic Drug Combinations Study in Ponies

Ketamin, Telazol, Xylazin och Detomidine: Ett jäm-förande försök mellan fem olika anestetikakombina-tioner hos ponnyn.

Acta Veterinaria Scandinavica volume 33, pages 109–115 (1992)Cite this article

Abstract

This study was designed to assess the effects of 5 anesthetic drug combinations in ponies: (1) ketamine 2.75 mg/kg, xylazine 1.0 mg/kg (KX), (2) Telazol® 1.65 mg/kg, xylazine 1.0 mg/kg (TX), (3) Telazol® 2 mg/kg, detomidine 20 µg/kg (TD-20), (4) Telazol® 2 mg/kg, detomidine 40 µg/kg (TD-40), (5) Telazol® 3 mg/kg, detomidine 60 µg/kg (TD-60). All drugs were given iv with xylazine or detomidine preceding ketamine or Telazol® by 5 min. Heart rate was decreased significantly from 5 min to arousal after TD-20 but only at 60 and 90 min after TD-40 and TD-60 respectively. Respiratory rate was decreased significantly for all ponies. Induction time did not differ between treatments. Duration of analgesia was 10 min for KX, 22.2 min for TX, 27.5 min for TD-20, 32.5 min for TD-40, and 70 min for TD-60. Arousal time was significantly longer with detomidine and Telazol®. Smoothness of recovery was judged best in ponies receiving KX and TD-40. All ponies stood unassisted 30 min after signs of arousal.

Sammanfattning

Detta Försök utfördes för att jämföra effekten av fem anestetikakombinationer hos ponnyn: (1) ketamin 2,75 mg/kg, xylazin 1,0 mg/kg (KX), (2) Telazol 1,65 mg/kg, zylazin 1,0 mg/kg (TX), (3) Telazol 2 mg/kg, detomidin 20 µg/kg (TD-20), (4) Telazol 2 mg/kg, detomidin 40 µg/kg (TD-40), (5) Telazol 3 mg/kg, detomidin 60 µg/kg (TD-60). Alia läkemedel gavs intravenöst; xylazin eller detomidin 5 min efter ketamin eller Telazol. Hjärtfrekvensen sjönk signifikant från 5 min till uppvaknandet efter TD-20 men endast vid 60 och 90 min respektivt. Andningsfrekvensen sjönk signifikant för alla ponnyn. Induktionstiden för de olika behandlingarna visade ingen skillnad. Analgesins duration var 10 min för KX, 22,2 min för TD-20, 32,5 min för TD-40 och 70 min för TD-60. Uppvakningstiden var signifikant längre med detomidin än med Telazol. Återhämtningen ansågs vara lugnast hos ponnyn som fått KX och TD-40. Alla ponnyn stod upprätta utan hjälp 30 min efter tecken på uppvakning.

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Authors and Affiliations

  1. Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, 36849-5522, Alabama, AL, USA

    H. C. Lin, K. R. Branson, J. C. Thurmon, G. J. Benson, W. J. Tranquilli, W. A. Olson & A. T. Vähä-Vahe

  2. Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, USA

    H. C. Lin, K. R. Branson, J. C. Thurmon, G. J. Benson, W. J. Tranquilli, W. A. Olson & A. T. Vähä-Vahe

  3. Research Center, Orion Corporation FARMOS, Turku, Finland

    H. C. Lin, K. R. Branson, J. C. Thurmon, G. J. Benson, W. J. Tranquilli, W. A. Olson & A. T. Vähä-Vahe

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  1. H. C. Lin
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  2. K. R. Branson
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  3. J. C. Thurmon
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  4. G. J. Benson
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  6. W. A. Olson
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  7. A. T. Vähä-Vahe
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Lin, H.C., Branson, K.R., Thurmon, J.C. et al. Ketamine, Telazol®, Xylazine and Detomidine. Acta Vet Scand 33, 109–115 (1992). https://doi.org/10.1186/BF03547317

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Acta Veterinaria Scandinavica

ISSN: 1751-0147