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The Role of Endotoxins in Induced Ruminal Acidosis in Calves

Betydelse av endotoxiner? I. Vid inducerad våmacidos hos kalv.

Acta Veterinaria Scandinavica volume 33, pages 117–127 (1992)Cite this article

Abstract

Experimentally induced ruminal acidosis was carried out in 4 calves to investigate the possibility of resorption of endotoxins from Gram negative bacteria originating from the gastro-intestinal tract. The ruminal acidosis was induced by overfeeding of oats and the effect was evaluated by clinical and blood biochemical changes. Blood samples were collected every 2 h for 60 h before and after experimental feeding. The animals showed signs of ruminal acidosis and also the clinical and blood biochemical changes were similar to those seen after experimental endotoxaemia. However, although being less dramatic the changes in many relevant parameters such as an increase in prostaglandin F metabolite levels, body temperature, endotoxins and a decrease in iron indicate that an endotoxaemic state had occurred. The results of the present study show that ruminal acidosis/stasis is linked to resorption of endotoxins from the gastro-intestinal tract causing endotoxaemia/endotoxicosis.

Sammanfattning

Experimentent inducerad våmacidos utfördes för att undersöka möjligheten av resorption av endotoxiner från Gram-negativa bakterier i magtarmkanalen hos kalv. Våmacidosen inducerades med överutfodring av havre och effekten utvärderades genom kliniska och blodkemiska förändringar. Blodprover samlades varannan timme i 60 t före och efter överutfodringen. Djuren visade tecken på våmacidos och både den kliniska och blodkemiska bilden liknar den som ses efter experimentell endotoxinämi. Förändringarna vid våmasidos var förvisso icke så dramatiska men många relavanta parametrar som t. ex. ökning av prostaglandin F2 α metaboliter, kroppstemperatur, endotoxiner och sänkning av järnnivåer indikerade att ett endotoxinämistadium förelåg. Resultaten från denna studie visar att våmacidos/stas är förenat med en resorption av endotoxiner från mag-tarmkanalen som orsakar endotoxinæmi/endotoxikos.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology and Department of Clinical Chemistry, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Department of Medical and Physiological Chemistry, Biomedical Centre and Department of Clinical Chemistry, University Hospital, University of Uppsala, Box 7039, S-750 07, Uppsala, Sweden

    S. Aiumlamai, H. Kindahl, G. Fredriksson, L.-E. Edqvist, L. Kulander & Ö. Eriksson

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  1. S. Aiumlamai
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  2. H. Kindahl
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  3. G. Fredriksson
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  4. L.-E. Edqvist
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  5. L. Kulander
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  6. Ö. Eriksson
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Aiumlamai, S., Kindahl, H., Fredriksson, G. et al. The Role of Endotoxins in Induced Ruminal Acidosis in Calves. Acta Vet Scand 33, 117–127 (1992). https://doi.org/10.1186/BF03547318

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Acta Veterinaria Scandinavica

ISSN: 1751-0147